BioTalentum Ltd., H-2100 Gödöllő, Hungary.
Department of Physiology and Animal Health, Institute of Physiology and Animal Health, Hungarian University of Agriculture and Life Sciences, H-2100 Gödöllő, Hungary.
Genes (Basel). 2021 Sep 30;12(10):1564. doi: 10.3390/genes12101564.
Non-communicable diseases (NCDs) sauch as diabetes, obesity and cardiovascular diseases are rising rapidly in all countries world-wide. Environmental maternal factors (e.g., diet, oxidative stress, drugs and many others), maternal illnesses and other stressors can predispose the newborn to develop diseases during different stages of life. The connection between environmental factors and NCDs was formulated by David Barker and colleagues as the Developmental Origins of Health and Disease (DOHaD) hypothesis. In this review, we describe the DOHaD concept and the effects of several environmental stressors on the health of the progeny, providing both animal and human evidence. We focus on cardiovascular diseases which represent the leading cause of death worldwide. The purpose of this review is to discuss how in vitro studies with pluripotent stem cells (PSCs), such as embryonic and induced pluripotent stem cells (ESC, iPSC), can underpin the research on non-genetic heart conditions. The PSCs could provide a tool to recapitulate aspects of embryonic development "in a dish", studying the effects of environmental exposure during cardiomyocyte (CM) differentiation and maturation, establishing a link to molecular mechanism and epigenetics.
非传染性疾病（NCDs）如糖尿病、肥胖症和心血管疾病在世界范围内所有国家都迅速增加。环境母体因素（如饮食、氧化应激、药物等）、母体疾病和其他应激源会使新生儿在生命的不同阶段易患疾病。David Barker 及其同事将环境因素与 NCDs 之间的联系归纳为健康与疾病的发育起源（DOHaD）假说。在这篇综述中，我们描述了 DOHaD 概念以及几种环境应激源对后代健康的影响，提供了动物和人类的证据。我们重点讨论了心血管疾病，它是全球范围内主要的死亡原因。本文的目的是讨论多能干细胞（PSCs），如胚胎干细胞和诱导多能干细胞（ESC、iPSC）的体外研究如何为非遗传性心脏病的研究提供依据。PSCs 可以提供一种工具，在“体外”再现胚胎发育的某些方面，研究在心肌细胞（CM）分化和成熟过程中环境暴露的影响，建立与分子机制和表观遗传学的联系。
