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HPA 轴相关基因的关联和遗传表达与自杀行为：系统综述。

Association and Genetic Expression between Genes Involved in HPA Axis and Suicide Behavior: A Systematic Review.

机构信息

División Académica Multidisciplinaria de Jalpa de Méndez, Universidad Juárez Autónoma de Tabasco, Jalpa de Méndez 86205, Tabasco, Mexico.

Laboratorio de Genómica de Enfermedades Psiquiátricas y Neurodegenerativas, Instituto Nacional de Medicina Genómica, Ciudad de México 14610, Mexico.

出版信息

Genes (Basel). 2021 Oct 13;12(10):1608. doi: 10.3390/genes12101608.

DOI:10.3390/genes12101608
PMID:34681002
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8536196/
Abstract

BACKGROUND

Suicide behavior (SB) has been highly associated with the response to stress and the hypothalamic-pituitary-adrenal (HPA) axis. The aim of this study was to summarize the results obtained in genetic studies that analyzed the HPA axis-stress pathway and SB through a systematic review.

METHODS

We performed an online search in PubMed, EBSCO, Web of Science, Scopus, and PsycoInfo databases up to May 2021. We followed the PRISMA guidelines for systematic reviews. We included case-control and expression studies that provided data on mRNA expression and single-nucleotide polymorphisms of genes associated with SB.

RESULTS

A total of 21,926 individuals participated across 41 studies (not repeats); 34 studies provided data on single-nucleotide polymorphisms in 21,284 participants and 11 studies reported data on mRNA expression in 1034 participants. Ten genes were identified: , , , , , , , , and .

CONCLUSIONS

Our findings suggest that key stress pathway genes are significantly associated with SB and show potential as biomarkers for SB.

摘要

背景

自杀行为（SB）与应激反应和下丘脑-垂体-肾上腺（HPA）轴高度相关。本研究旨在通过系统评价总结分析 HPA 轴-应激途径与 SB 的遗传研究结果。

方法

我们在 PubMed、EBSCO、Web of Science、Scopus 和 PsycoInfo 数据库中进行了在线搜索，截至 2021 年 5 月。我们遵循 PRISMA 系统评价指南。我们纳入了提供与 SB 相关基因的 mRNA 表达和单核苷酸多态性数据的病例对照和表达研究。

结果

共有 21926 名个体参与了 41 项研究（非重复）；34 项研究在 21284 名参与者中提供了单核苷酸多态性数据，11 项研究在 1034 名参与者中报告了 mRNA 表达数据。确定了 10 个基因： 、 、 、 、 、 、 、 、 。

结论

我们的研究结果表明，关键应激途径基因与 SB 显著相关，并显示出作为 SB 生物标志物的潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1675/8536196/d17164e50634/genes-12-01608-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1675/8536196/dc45147e2816/genes-12-01608-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1675/8536196/d17164e50634/genes-12-01608-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1675/8536196/dc45147e2816/genes-12-01608-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1675/8536196/d17164e50634/genes-12-01608-g002.jpg

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