Nam Hyeon-Hwa, Nan Li, Choo Byung-Kil
Herbal Medicine Resources Research Center, Korea Institute of Oriental Medicine, Naju-si 58245, Korea.
Agricultural College, Yanbian University, Yanji 133002, China.
Foods. 2021 Oct 18;10(10):2500. doi: 10.3390/foods10102500.
L. (dill seeds) are important medicinal and functional foods in Europe and central and south Asia, often used as a seasoning in daily diets. L. seeds (AGS) are used to treat indigestion and have shown physiological activities such as those against hypoglycemia and gastroesophageal disease. This study explored the protective effects of AGS extract on mucosal damages and inflammation in reflux esophagitis rats. AGS inhibited cellular inflammation including NO production and the expression of inflammatory proteins (iNOS and COX2 etc.), cytokines (IL-1β and TNF-α) and nuclear transfer factor related to NF-κB signaling caused by LPS stimulation in vitro. Furthermore, reflux esophagitis-induced rats were used to observe the anti-inflammatory effect of AGS. Tissue staining and inflammation-related protein expression of rats with acute reflux esophagitis indicated that AGS improved this inflammatory response, such as COX-2 and TNF-α in mucosa. In conclusion, AGS have good physiological activity and the possibility of being used as a medicinal food and a functional resource for the prevention and therapy of gastroesophageal diseases.
莳萝（莳萝籽）在欧洲以及中亚和南亚是重要的药用和功能性食品，常被用作日常饮食中的调味料。莳萝籽提取物（AGS）可用于治疗消化不良，并已显示出诸如抗低血糖和抗胃食管疾病等生理活性。本研究探讨了AGS提取物对反流性食管炎大鼠黏膜损伤和炎症的保护作用。AGS在体外可抑制细胞炎症，包括一氧化氮（NO）的产生、炎症蛋白（诱导型一氧化氮合酶和环氧化酶2等）、细胞因子（白细胞介素-1β和肿瘤坏死因子-α）的表达以及与脂多糖（LPS）刺激引起的核转录因子κB（NF-κB）信号通路相关的核转移。此外，利用反流性食管炎诱导大鼠观察AGS的抗炎作用。急性反流性食管炎大鼠的组织染色和炎症相关蛋白表达表明，AGS改善了这种炎症反应，如黏膜中环氧化酶-2和肿瘤坏死因子-α的表达。总之，AGS具有良好的生理活性，有可能作为药用食品和功能性资源用于胃食管疾病的预防和治疗。
Zotero 插件
