Department of Pharmacology & Nutritional Sciences and Markey Cancer Center, University of Kentucky School of Medicine, Lexington, KY 40506, USA.
Int J Mol Sci. 2021 Oct 14;22(20):11062. doi: 10.3390/ijms222011062.
SNAI1, a zinc finger transcription factor, not only acts as the master regulator of epithelial-mesenchymal transition (EMT) but also functions as a driver of cancer progression, including cell invasion, survival, immune regulation, stem cell properties, and metabolic regulation. The regulation of SNAI1 occurs at the transcriptional, translational, and predominant post-translational levels including phosphorylation, acetylation, and ubiquitination. Here, we discuss the regulation and role of SNAI1 in cancer metastasis, with a particular emphasis on epigenetic regulation and post-translational modifications. Understanding how signaling networks integrate with SNAI1 in cancer progression will shed new light on the mechanism of tumor metastasis and help develop novel therapeutic strategies against cancer metastasis.
SNAI1 是一个锌指转录因子，不仅作为上皮-间充质转化（EMT）的主要调节因子，而且还作为癌症进展的驱动因子，包括细胞侵袭、存活、免疫调节、干细胞特性和代谢调节。SNAI1 的调节发生在转录、翻译和主要的翻译后水平，包括磷酸化、乙酰化和泛素化。在这里，我们讨论了 SNAI1 在癌症转移中的调节和作用，特别强调了表观遗传调控和翻译后修饰。了解信号网络如何与癌症进展中的 SNAI1 整合将为肿瘤转移的机制提供新的见解，并有助于开发针对癌症转移的新的治疗策略。
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