白细胞介素-15 在妊娠结局中的作用。
Interleukin-15 in Outcomes of Pregnancy.
机构信息
Division of Neonatology, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
出版信息
Int J Mol Sci. 2021 Oct 14;22(20):11094. doi: 10.3390/ijms222011094.
Abstract
Interleukin-15 (IL-15) is a pleiotropic cytokine that classically acts to support the development, maintenance, and function of killer lymphocytes. IL-15 is abundant in the uterus prior to and during pregnancy, but it is subject to tight spatial and temporal regulation. Both mouse models and human studies suggest that homeostasis of IL-15 is essential for healthy pregnancy. Dysregulation of IL-15 is associated with adverse outcomes of pregnancy. Herein, we review producers of IL-15 and responders to IL-15, including non-traditional responders in the maternal uterus and fetal placenta. We also review regulation of IL-15 at the maternal-fetal interface and propose mechanisms of action of IL-15 to facilitate additional study of this critical cytokine in the context of pregnancy.
摘要
白细胞介素-15（IL-15）是一种多效细胞因子，经典作用是支持杀伤淋巴细胞的发育、维持和功能。IL-15 在妊娠前和妊娠期间在子宫中大量存在，但受到严格的时空调节。小鼠模型和人类研究均表明，IL-15 的稳态对于健康妊娠至关重要。IL-15 的失调与妊娠不良结局有关。本文综述了 IL-15 的产生者和对 IL-15 的应答者，包括母体子宫和胎儿胎盘中的非传统应答者。我们还综述了母体-胎儿界面处 IL-15 的调节，并提出了 IL-15 的作用机制，以促进在妊娠背景下对这种关键细胞因子的进一步研究。
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