Graduate Institute of Toxicology, College of Medicine, National Taiwan University, Taipei 106, Taiwan.
Department of Anesthesiology, Far-Eastern Memorial Hospital, New Taipei City 22060, Taiwan.
Int J Mol Sci. 2021 Oct 18;22(20):11237. doi: 10.3390/ijms222011237.
Ochratoxin A (OTA) is a mycotoxin widely found in various foods and feeds that have a deleterious effect on humans and animals. It has been shown that OTA causes multiorgan toxicity, and the kidney is the main target of OTA among them. This present article aims to review recent and latest intracellular molecular interactions and signaling pathways of OTA-induced nephrotoxicity. Pyroptosis, lipotoxicity, organic anionic membrane transporter, autophagy, the ubiquitin-proteasome system, and histone acetyltransferase have been involved in the renal toxicity caused by OTA. Meanwhile, the literature reviewed the alternative or method against OTA toxicity by reducing ROS production, oxidative stress, activating the Nrf2 pathway, through using nanoparticles, a natural flavonoid, and metal supplement. The present review discloses the molecular mechanism of OTA-induced nephrotoxicity, providing opinions and strategies against OTA toxicity.
赭曲霉毒素 A（OTA）是一种广泛存在于各种食品和饲料中的真菌毒素，对人类和动物具有有害影响。已经表明，OTA 会导致多器官毒性，而其中肾脏是 OTA 的主要靶器官。本文旨在综述 OTA 诱导的肾毒性的最新和最新的细胞内分子相互作用和信号通路。细胞焦亡、脂毒性、有机阴离子膜转运体、自噬、泛素-蛋白酶体系统和组蛋白乙酰转移酶已被涉及到 OTA 引起的肾毒性中。同时，本文综述了通过减少 ROS 产生、氧化应激、通过使用纳米粒子、天然类黄酮和金属补充剂激活 Nrf2 途径来对抗 OTA 毒性的替代或方法。本综述揭示了 OTA 诱导的肾毒性的分子机制，为对抗 OTA 毒性提供了意见和策略。
