Pauwels R P, Smeets W W, Geraedts J P, Debruyne F M
J Urol. 1987 Feb;137(2):210-5. doi: 10.1016/s0022-5347(17)43956-5.
Tissue specimens from 96 patients with urothelial cell carcinoma were subjected to cytogenetic examination to determine whether there is a correlation between chromosomal abnormalities and tumor behavior. Recognizable metaphases were found in 43 patients (45 per cent). The range in chromosomal counts appeared to be a better reflection of invasion than the modal number. Noninvasive tumors nearly always were hypodiploid or diploid. All invasive tumors showed hyperploid cells. Cytogenetically, there was no difference between invasive grade 2 and grade 3 tumors. During our limited followup tumor progression was found only in tumors with hyperploid cells. With a direct technique we found no difference in the frequency of marker chromosomes according to tumor stage and grade.
对96例尿路上皮细胞癌患者的组织标本进行细胞遗传学检查，以确定染色体异常与肿瘤行为之间是否存在相关性。在43例患者（45%）中发现了可识别的中期相。染色体计数范围似乎比众数更能反映侵袭情况。非侵袭性肿瘤几乎总是亚二倍体或二倍体。所有侵袭性肿瘤均显示超二倍体细胞。细胞遗传学上，侵袭性2级和3级肿瘤之间没有差异。在我们有限的随访期间，仅在具有超二倍体细胞的肿瘤中发现肿瘤进展。采用直接技术，我们发现标记染色体的频率根据肿瘤分期和分级没有差异。
