细胞遗传学分析：早期膀胱癌复发的一个潜在指标。

Cytogenetic analysis: a potential index for recurrence of early carcinoma of the bladder.

作者信息

Falor W H, Ward R M

出版信息

J Urol. 1976 Jan;115(1):49-52. doi: 10.1016/s0022-5347(17)59063-1.

Abstract

In 15 cancer patients cystoscopic resection or biopsy coupled with cytogenetic analysis at intervals of 3 to 69 months showed persistence of chromosomal patterns with markers (abnormal chromosomes) in 4 of 7 non-invasive and in 6 of 8 submucosal invasive carcinomas. Recurrence was limited to but constant in those carcinomas containing markers. Marker chromosomes have potential value as a prognostic aid. Further, the triad of tetraploidy, markers and submucusal invasive moderately well differentiated carcinoma appears to carry such a lethal prognosis as to militate for early radical resection.

摘要

在15例癌症患者中，进行膀胱镜检查切除或活检并每隔3至69个月进行细胞遗传学分析，结果显示，在7例非浸润性癌中的4例以及8例黏膜下浸润性癌中的6例中，带有标记（异常染色体）的染色体模式持续存在。复发仅限于那些含有标记的癌症，但复发情况持续存在。标记染色体作为一种预后辅助手段具有潜在价值。此外，四倍体、标记和黏膜下浸润性中度分化良好的癌这三者组合似乎预示着如此致命的预后，因此主张早期进行根治性切除。