Bode U, Erps M, Liappis N
Klin Padiatr. 1986 Nov-Dec;198(6):476-8. doi: 10.1055/s-2008-1033910.
Children receiving cytotoxic drugs were given 7 S IgG or placebo before the period of neutropenia (less than 500/mm3 neutrophils) in a double-blind study. Though the IgG levels differed significantly, fever as the most reliable sign of infection occurred not less often than in the placebo-group. There is no indication for the routinely prophylactic administration of immunoglobulins to oncological patients. The therapeutic benefit of immunoglobulin substitution in cancer patients needs verification.
在一项双盲研究中，在中性粒细胞减少期（中性粒细胞少于500/mm³）之前，给接受细胞毒性药物治疗的儿童注射7S IgG或安慰剂。尽管IgG水平有显著差异，但作为感染最可靠指标的发热出现的频率并不低于安慰剂组。没有迹象表明需要对肿瘤患者常规预防性给予免疫球蛋白。癌症患者免疫球蛋白替代治疗的益处需要验证。
