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新药给急性髓系白血病带来新挑战:简要综述

New Drugs Bringing New Challenges to AML: A Brief Review.

作者信息

Yeoh Zhi Han, Bajel Ashish, Wei Andrew H

机构信息

Department of Clinical Haematology, Peter MacCallum Cancer Centre & The Royal Melbourne Hospital, Melbourne, VIC 3000, Australia.

The Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, VIC 3000, Australia.

出版信息

J Pers Med. 2021 Oct 3;11(10):1003. doi: 10.3390/jpm11101003.

DOI:10.3390/jpm11101003
PMID:34683144
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8537004/
Abstract

The better understanding of the genomic landscape in acute myeloid leukaemia (AML) has progressively paved the way for precision medicine in AML. There is a growing number of drugs with novel mechanisms of action and unique side-effect profiles. This review examines the impact of evolving novel therapies on survival in AML and the challenges that ensue.

摘要

对急性髓系白血病(AML)基因组格局的深入了解逐渐为AML的精准医学铺平了道路。具有新作用机制和独特副作用特征的药物越来越多。本综述探讨了不断发展的新疗法对AML患者生存的影响以及随之而来的挑战。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4037/8537004/85e27b21e602/jpm-11-01003-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4037/8537004/85e27b21e602/jpm-11-01003-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4037/8537004/85e27b21e602/jpm-11-01003-g001.jpg

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Leukemia. 2021 Jul;35(7):1843-1863. doi: 10.1038/s41375-021-01253-x. Epub 2021 May 5.
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Prognostic significance of concurrent gene mutations in intensively treated patients with IDH-mutated AML: an ALFA study.强化治疗的 IDH 突变型 AML 患者同时存在基因突变的预后意义:ALFA 研究。
Blood. 2021 May 20;137(20):2827-2837. doi: 10.1182/blood.2020010165.
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