Bray Eric R, Oropallo Alisha R, Grande Daniel A, Kirsner Robert S, Badiavas Evangelos V
Phillip Frost Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, FL 33136, USA.
Interdisciplinary Stem Cell Institute, University of Miami Miller School of Medicine, Miami, FL 33136, USA.
Pharmaceutics. 2021 Sep 23;13(10):1543. doi: 10.3390/pharmaceutics13101543.
Chronic wounds develop when the orderly process of cutaneous wound healing is delayed or disrupted. Development of a chronic wound is associated with significant morbidity and financial burden to the individual and health-care system. Therefore, new therapeutic modalities are needed to address this serious condition. Mesenchymal stem cells (MSCs) promote skin repair, but their clinical use has been limited due to technical challenges. Extracellular vesicles (EVs) are particles released by cells that carry bioactive molecules (lipids, proteins, and nucleic acids) and regulate intercellular communication. EVs (exosomes, microvesicles, and apoptotic bodies) mediate key therapeutic effects of MSCs. In this review we examine the experimental data establishing a role for EVs in wound healing. Then, we explore techniques for designing EVs to function as a targeted drug delivery system and how EVs can be incorporated into biomaterials to produce a personalized wound dressing. Finally, we discuss the status of clinically deploying EVs as a therapeutic agent in wound care.
当皮肤伤口愈合的有序过程被延迟或中断时，慢性伤口就会形成。慢性伤口的形成会给个人和医疗保健系统带来重大的发病率和经济负担。因此，需要新的治疗方法来应对这种严重情况。间充质干细胞（MSCs）可促进皮肤修复，但其临床应用由于技术挑战而受到限制。细胞外囊泡（EVs）是细胞释放的携带生物活性分子（脂质、蛋白质和核酸）并调节细胞间通讯的颗粒。EVs（外泌体、微泡和凋亡小体）介导MSCs的关键治疗作用。在这篇综述中，我们研究了确定EVs在伤口愈合中作用的实验数据。然后，我们探索设计EVs作为靶向药物递送系统的技术，以及如何将EVs整合到生物材料中以生产个性化伤口敷料。最后，我们讨论了在伤口护理中将EVs作为治疗剂进行临床应用的现状。
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