Pharmacognosy Department, Faculty of Pharmacy, Cairo University, Kasr-El-Aini Street, Cairo 11562, Egypt.
Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt.
Molecules. 2021 Oct 17;26(20):6284. doi: 10.3390/molecules26206284.
The demand for natural fungicides to replace synthetic ones has surged since toxic residues persist in soils, causing environmental contamination and posing a serious threat to worldwide public health. In the context of crop protection and enhancing the efficiency and safety of fungicides, nanotechnology is an eco-friendly strategy in managing fungal pathogens. In the present study, essential oils were isolated from the peels of four citrus fruits (, , , and ) and were investigated using gas chromatography-mass spectrometric analysis. Monoterpene hydrocarbon was the most predominant group and limonene was the most abundant in the four oils. The antifungal potential of the oils was investigated, and the most active oil () was loaded into hexosomal dispersion, and its antifungal potential was retested against the same fungi. The structurally unique nano-based formulation showed great potency for fungal control. To the best of our knowledge, it is the first time the oil of in nano-hexosomes has been formulated and its fungicidal activity examined. The data collected suggest that citrus essential oils (CEOs), especially when nano-formulated, could be successfully used in integrated fungus management programs.
由于有毒残留物残留在土壤中，导致环境污染，并对全球公众健康构成严重威胁，因此对天然杀菌剂替代合成杀菌剂的需求激增。在作物保护和提高杀菌剂效率和安全性的背景下，纳米技术是管理真菌病原体的一种环保策略。在本研究中，从四种柑橘果皮（、、、和）中分离出精油，并使用气相色谱-质谱分析进行了研究。单萜烃是最主要的组，四种油中柠檬烯含量最丰富。研究了精油的抗真菌潜力，最活跃的油（）被装入六方分散体中，并对其针对相同真菌的抗真菌潜力进行了重新测试。这种结构独特的基于纳米的制剂对真菌控制具有很强的效力。据我们所知，这是首次将纳米六方体中的 油制成并检测其杀菌活性。收集的数据表明，柑橘精油（CEOs），特别是纳米制剂，可成功用于综合真菌管理计划。
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