Jain Nityanand, Jansone Inese, Obidenova Tatjana, Sīmanis Raimonds, Meisters Jānis, Straupmane Dagnija, Reinis Aigars
Department of Biology and Microbiology, Faculty of Medicine, Riga Stradiņš University, Dzirciema Street 16, LV-1007 Riga, Latvia.
Joint Laboratory, Pauls Stradiņš Clinical University Hospital, LV-1002 Riga, Latvia.
Life (Basel). 2021 Sep 23;11(10):1002. doi: 10.3390/life11101002.
Nosocomial fungal infections are an emerging global public health threat that requires urgent attention and proper management. With the limited availability of treatment options, it has become necessary to understand the emerging epidemiological trends, mechanisms, and risk factors. However, very limited surveillance reports are available in the Latvian and broader European context. We therefore conducted a retrospective analysis of laboratory data (2017-2020) from Pauls Stradinš Clinical University Hospital (PSCUH), Riga, Latvia, which is one of the largest public multispecialty hospitals in Latvia. A total of 2278 fungal isolates were analyzed during the study period, with spp. comprising 95% of the isolates, followed by spp. and spp. Amongst the spp., and made up about 75% of the isolates. The Department of Lung Diseases and Thoracic Surgery had the highest caseload followed by Intensive Care Department. Majority of the fungal isolates were collected from the bronchoalveolar lavage (37%), followed by urine (19%) and sputum (18%) samples. A total of 34 cases of candidemia were noted during the study period with being the most common candidemia pathogen. Proper surveillance of emerging epidemiological trends serve as the most reliable and powerful cornerstone towards tackling this emerging threat.
医院获得性真菌感染是一种新出现的全球公共卫生威胁，需要紧急关注和妥善管理。由于治疗选择有限，了解新出现的流行病学趋势、机制和风险因素变得很有必要。然而，在拉脱维亚及更广泛的欧洲范围内，监测报告非常有限。因此，我们对拉脱维亚里加的保罗·斯特拉迪尼斯临床大学医院（PSCUH）的实验室数据（2017 - 2020年）进行了回顾性分析，该医院是拉脱维亚最大的公立多专科医院之一。在研究期间共分析了2278株真菌分离株，其中 spp. 占分离株的95%，其次是 spp. 和 spp.。在 spp. 中， 和 约占分离株的75%。肺病和胸外科的病例数最多，其次是重症监护科。大多数真菌分离株来自支气管肺泡灌洗样本（37%），其次是尿液（19%）和痰液（18%）样本。在研究期间共记录了34例念珠菌血症病例，其中 是最常见的念珠菌血症病原体。对新出现的流行病学趋势进行适当监测是应对这一新兴威胁最可靠、最有力的基石。
