SEA 和 GATOR 十周年回顾。

CNRS UMR9018, Institut Gustave Roussy, Université Paris-Saclay, 94805 Villejuif, France.

Cells. 2021 Oct 8;10(10):2689. doi: 10.3390/cells10102689.

The SEA complex was described for the first time in yeast ten years ago, and its human homologue GATOR complex two years later. During the past decade, many advances on the SEA/GATOR biology in different organisms have been made that allowed its role as an essential upstream regulator of the mTORC1 pathway to be defined. In this review, we describe these advances in relation to the identification of multiple functions of the SEA/GATOR complex in nutrient response and beyond and highlight the consequence of GATOR mutations in cancer and neurodegenerative diseases.

SEA 复合物十年前在酵母中首次被描述，其人类同源物 GATOR 复合物两年后被描述。在过去的十年中，在不同生物体中的 SEA/GATOR 生物学方面取得了许多进展，这些进展使得它作为 mTORC1 途径的必要上游调节剂的作用得以确定。在这篇综述中，我们描述了这些进展与 SEA/GATOR 复合物在营养响应及其他方面的多种功能的鉴定有关，并强调了 GATOR 突变在癌症和神经退行性疾病中的后果。