Inserm UMR1141 NeuroDiderot, Université de Paris, 75019 Paris, France.
Pediatric and Neonatal Intensive Care Unit, Armand-Trousseau University Hospital, Assistance Publique-Hôpitaux de Paris, Sorbonne University, 75019 Paris, France.
Cells. 2021 Oct 15;10(10):2766. doi: 10.3390/cells10102766.
Cerebral stroke, traumatic brain injury, and hypoxic ischemic encephalopathy are among the most frequently occurring brain injuries. A complex pathogenesis, characterized by a synergistic interaction between alterations of the cerebrovascular system, cell death, and inflammation, is at the basis of the brain damage that leads to behavioral and neurodevelopmental disabilities in affected subjects. Sildenafil is a selective inhibitor of the enzyme phosphodiesterase 5 (PDE5) that is able to cross the blood-brain barrier. Preclinical data suggest that sildenafil may be a good candidate for the prevention or repair of brain injury in both adults and neonates. The aim of this review is to summarize the evidence supporting the neuroprotective action of sildenafil and discuss the possible benefits of the association of sildenafil with current therapeutic strategies.
脑卒、创伤性脑损伤和缺氧缺血性脑病是最常见的脑损伤类型之一。一种复杂的发病机制，其特征是脑血管系统改变、细胞死亡和炎症之间的协同相互作用，是导致受影响患者出现行为和神经发育障碍的脑损伤的基础。西地那非是一种选择性磷酸二酯酶 5（PDE5）抑制剂，能够穿过血脑屏障。临床前数据表明，西地那非可能是预防或修复成人和新生儿脑损伤的一个很好的候选药物。本综述的目的是总结支持西地那非神经保护作用的证据，并讨论西地那非与当前治疗策略联合应用的可能益处。
