Meurman J H, Murtomaa H
Scand J Dent Res. 1986 Dec;94(6):491-9. doi: 10.1111/j.1600-0722.1986.tb01791.x.
Eight effervescent preparations and one chewable vitamin C preparation were tested with regard to dental erosion by immersing bovine tooth specimens for 100 h in 100 ml of the test solutions. For comparison, two effervescent calcium preparations were studied. All the vitamin C products caused distinct erosion and disclosure of dentin in the specimens which could not be found in calcium preparations. Calcium release from the bovine teeth varied from 1.08 to 12.99 micrograms Ca/mm2/h. Softening of the dental tissue assessed as the Vickers hardness units, was most prominent among the specimens where most calcium release was observed. A crossover clinical trial using a test pannel assigned to 1-week periods of excellent vs no mechanical cleaning, and with a consumption of 6.6 times more vitamin C tablets than the recommended daily use, revealed no particular impact of the preparation on a variety of oral health parameters. Except for a slight stimulation of the subjects' salivary flow rate 30 min after consuming the vitamin C, all other differences observed could be explained by the accumulation of plaque during the period without mechanical cleaning. Thus, in patients with normal salivary flow rate a short-term consumption of vitamin C preparations, even in excess, may be regarded as harmless from the dental point of view. However, all the studied preparations are potentially erosive if left in direct contact with the teeth.
通过将牛牙标本浸泡在100毫升测试溶液中100小时,对8种泡腾制剂和1种咀嚼型维生素C制剂进行了牙齿侵蚀测试。作为对照,研究了2种泡腾钙制剂。所有维生素C产品都会导致标本中的牙本质出现明显侵蚀和暴露,而钙制剂中未出现这种情况。牛牙中的钙释放量在1.08至12.99微克钙/平方毫米/小时之间。以维氏硬度单位评估的牙齿组织软化,在观察到钙释放量最多的标本中最为明显。一项交叉临床试验使用了一个测试小组,该小组被分配到为期1周的极佳与无机械清洁周期,并且维生素C片的摄入量比推荐日用量多6.6倍,结果显示该制剂对各种口腔健康参数没有特别影响。除了在服用维生素C后30分钟对受试者唾液流速有轻微刺激外,观察到的所有其他差异都可以用无机械清洁期间牙菌斑的积累来解释。因此,从牙齿角度来看,对于唾液流速正常的患者,短期服用维生素C制剂,即使过量,也可能被视为无害。然而,如果所有研究的制剂直接与牙齿接触,都有潜在的腐蚀性。