McMillan R M, MacIntyre D E, Gordon J L
J Pharm Pharmacol. 1979 Mar;31(3):148-52. doi: 10.1111/j.2042-7158.1979.tb13457.x.
The rank order of four carrageenans tested as inducers of human platelet aggregation was the same (iota greater than lambda greater than gelcarin greater than kappa) as their relative inflammatory potencies in vivo. All four carrageenans caused some precipitation of plasma proteins, and induced aggregation in platelet-rich plasma or washed platelet suspensions. The second phase of aggregation was citrate-dependent and associated with secretion of 5-hydroxytryptamine and lysosomal enzymes. Platelets could provide a useful model for investigating the actions of carrageenans on cell membranes.
作为人类血小板聚集诱导剂进行测试的四种角叉菜胶的等级顺序（ι型大于λ型大于吉兰糖胶大于κ型）与其在体内的相对炎症效力相同。所有四种角叉菜胶都会导致血浆蛋白出现一定程度的沉淀，并在富血小板血浆或洗涤后的血小板悬浮液中诱导聚集。聚集的第二阶段依赖于柠檬酸盐，并与5-羟色胺和溶酶体酶的分泌有关。血小板可为研究角叉菜胶对细胞膜的作用提供一个有用的模型。
