Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland.
National Institute for Health Research Bristol Biomedical Research Centre, University Hospitals Bristol and Weston NHS Foundation Trust and the University of Bristol, United Kingdom; Translational Health Sciences, Bristol Medical School, Musculoskeletal Research Unit, University of Bristol, Bristol, United Kingdom.
Prev Med. 2021 Dec;153:106858. doi: 10.1016/j.ypmed.2021.106858. Epub 2021 Oct 20.
Population-wide preventive measures constitute important approaches towards reducing stroke risk and its associated burden. We sought to examine the association between American Heart Association's (AHA) Life's Simple7 (LS7) score and the risk of stroke in men.
The study is based on the prospective population-based Kuopio Ischaemic Heart Disease cohort comprising men (42-60 years) without pre-existing history of stroke at baseline (1984-1989). LS7 was computed from AHA's cardiovascular health metrics for 2520 men and includes data on diet, physical activity, body mass index, smoking status, blood pressures, total cholesterol and blood glucose. Participants were classified into three LS7 groups based on the number of ideal metrics: low (0-2), medium (3-4) and high (5-7). Multivariable Cox regression models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) of LS7 scores for total and ischaemic stroke.
During a median follow-up of 26 years, 428 total and 362 ischaemic incident stroke events were recorded. The risk of both stroke outcomes decreased continuously with increasing LS7 scores across the range 2-6. Men with high LS7 had 48% (HR: 0.52; 95%CI: 0.32-0.86) lower risk of total stroke when compared with those with low LS7. The association was similar for the risk of ischaemic stroke, with 50% (HR: 0.50; 95%CI: 0.29-0.87) lower risk among men with high LS7 compared with those with low LS7.
LS7 was strongly, inversely and linearly associated with risk of total and ischaemic strokes among a middle-aged male Finnish population.
人群范围的预防措施是降低中风风险及其相关负担的重要手段。我们旨在研究美国心脏协会（AHA）的生活简单 7 项指标（LS7）评分与男性中风风险之间的关联。
该研究基于前瞻性人群为基础的库奥皮奥缺血性心脏病队列，包括基线时（1984-1989 年）无既往中风史的男性（42-60 岁）。LS7 根据 AHA 的心血管健康指标计算得出，共纳入 2520 名男性，包括饮食、体力活动、体重指数、吸烟状况、血压、总胆固醇和血糖数据。根据理想指标的数量，参与者被分为三组 LS7 评分：低（0-2）、中（3-4）和高（5-7）。多变量 Cox 回归模型用于估计 LS7 评分与总中风和缺血性中风的风险比（HR）和 95%置信区间（CI）。
在中位随访 26 年期间，记录了 428 例总中风和 362 例缺血性中风事件。风险随着 LS7 评分的增加而连续降低，范围在 2-6 分之间。与 LS7 评分低的男性相比，LS7 评分高的男性总中风风险降低 48%（HR：0.52；95%CI：0.32-0.86）。对于缺血性中风风险，LS7 评分高的男性风险降低 50%（HR：0.50；95%CI：0.29-0.87），与 LS7 评分低的男性相似。
在芬兰中年男性人群中，LS7 与总中风和缺血性中风的风险呈强烈、反向和线性相关。
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