Institute of Clinical Medicine, University of Eastern Finland, Yliopistonranta 1, 70211 Kuopio, Finland.
Diabetes Research Centre, University of Leicester, Leicester General Hospital, Gwendolen Road, Leicester, LE5 4WP, UK.
Eur J Prev Cardiol. 2023 Jun 1;30(8):658-667. doi: 10.1093/eurjpc/zwad040.
The aim of the study was to examine the association between Life's Essential 8 (LE8) and the risk of cardiovascular and all-cause mortality.
The LE8 was computed for 1662 men, aged 42-60 years, without pre-existing history of cardiovascular disease (CVD) at baseline in the Kuopio Ischaemic Heart Disease study. The LE8 factors include diet, physical activity, nicotine exposure, sleep, body mass index, blood pressure, blood glucose, and lipids. Each LE8 factor was scored between 0 and 100 points. The summation of all points generated the total LE8 score, which was categorized into quartiles ≤-420, >420-485, >485-550, and >550. Multivariable Cox regression models were used to estimate hazard ratios and 95% confidence intervals of LE8 scores for the outcomes. During a median follow-up of 30 years, 402 and 987 men died from CVD and any cause, respectively. The total LE8 score among participants ranged from 185 to 750. The higher the LE8 scores, the lower the risk of dying from CVD and all-cause. Following adjustment for age, alcohol consumption, and socio-economic status, every 50-unit increase in LE8 score was associated with 17% and 14% lower risk of CVD and all-cause deaths, respectively. Men within LE8 top quartile had 60% lower risk of CVD mortality when compared with those within the bottom quartile.
Life's Essential 8 was strongly and inversely associated with the risk of CVD death and all-cause mortality among ageing men. Measures that promote optimal LE8 scores should be encouraged among the general population.
本研究旨在探讨生命的基本 8 项（LE8）与心血管疾病和全因死亡风险之间的关系。
在库奥皮奥缺血性心脏病研究中，我们对 1662 名年龄在 42-60 岁、基线时无心血管疾病（CVD）既往史的男性进行了 LE8 评估。LE8 因素包括饮食、身体活动、尼古丁暴露、睡眠、体重指数、血压、血糖和血脂。每个 LE8 因素的评分范围为 0-100 分。所有分数的总和生成总 LE8 评分，将其分为四个四分位数：≤-420、>420-485、>485-550 和 >550。多变量 Cox 回归模型用于估计 LE8 评分与结局的风险比和 95%置信区间。在中位随访 30 年期间，402 名和 987 名男性分别死于 CVD 和任何原因。参与者的总 LE8 评分范围为 185-750。LE8 评分越高，死于 CVD 和全因的风险越低。在校正年龄、饮酒和社会经济地位后，LE8 评分每增加 50 个单位，与 CVD 和全因死亡风险分别降低 17%和 14%相关。与 LE8 评分最低四分位的男性相比，处于 LE8 评分最高四分位的男性 CVD 死亡率降低 60%。
LE8 与老年男性 CVD 死亡和全因死亡率呈强烈的负相关。应鼓励在普通人群中采取措施促进最佳 LE8 评分。
