Suppr超能文献

在 DNA 修复之舞中为组蛋白伴舞。

Chaperoning histones at the DNA repair dance.

机构信息

Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, 1300 York Avenue, New York, NY 10065, USA.

Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, 1300 York Avenue, New York, NY 10065, USA.

出版信息

DNA Repair (Amst). 2021 Dec;108:103240. doi: 10.1016/j.dnarep.2021.103240. Epub 2021 Oct 13.

Abstract

Unlike all other biological molecules that are degraded and replaced if damaged, DNA must be repaired as chromosomes cannot be replaced. Indeed, DNA endures a wide variety of structural damage that need to be repaired accurately to maintain genomic stability and proper functioning of cells and to prevent mutation leading to disease. Given that the genome is packaged into chromatin within eukaryotic cells, it has become increasingly evident that the chromatin context of DNA both facilitates and regulates DNA repair processes. In this review, we discuss mechanisms involved in removal of histones (chromatin disassembly) from around DNA lesions, by histone chaperones and chromatin remodelers, that promotes accessibility of the DNA repair machinery. We also elaborate on how the deposition of core histones and specific histone variants onto DNA (chromatin assembly) during DNA repair promotes repair processes, the role of histone post translational modifications in these processes and how chromatin structure is reestablished after DNA repair is complete.

摘要

与所有其他受损后会被降解和替换的生物分子不同,如果受损,染色体不能被替换,因此 DNA 必须被修复。事实上,DNA 会承受各种各样的结构损伤,为了维持基因组稳定性和细胞的正常功能,防止导致疾病的突变,这些损伤需要被准确修复。鉴于真核细胞中的基因组被包装成染色质,越来越明显的是,DNA 的染色质环境既促进又调节 DNA 修复过程。在这篇综述中,我们讨论了通过组蛋白伴侣和染色质重塑因子从 DNA 损伤处去除组蛋白(染色质解组装)的机制,这些机制促进了 DNA 修复机制的可及性。我们还详细阐述了在 DNA 修复过程中核心组蛋白和特定组蛋白变体在 DNA 上的沉积(染色质组装)如何促进修复过程,组蛋白翻译后修饰在这些过程中的作用,以及在 DNA 修复完成后如何重建染色质结构。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/335d/8827131/b082260ac3bd/nihms-1771675-f0001.jpg

相似文献

1
Chaperoning histones at the DNA repair dance.在 DNA 修复之舞中为组蛋白伴舞。
DNA Repair (Amst). 2021 Dec;108:103240. doi: 10.1016/j.dnarep.2021.103240. Epub 2021 Oct 13.
2
Reshaping chromatin after DNA damage: the choreography of histone proteins.DNA损伤后重塑染色质:组蛋白的编排
J Mol Biol. 2015 Feb 13;427(3):626-36. doi: 10.1016/j.jmb.2014.05.025. Epub 2014 Jun 2.
3
Chromatin reassembly signals the end of DNA repair.染色质重新组装标志着DNA修复的结束。
Cell Cycle. 2008 Dec 15;7(24):3792-7. doi: 10.4161/cc.7.24.7188. Epub 2008 Dec 13.
4
Histone variants: the artists of eukaryotic chromatin.组蛋白变体:真核染色质的艺术家。
Sci China Life Sci. 2015 Mar;58(3):232-9. doi: 10.1007/s11427-015-4817-4. Epub 2015 Feb 14.
5
Chromatin dynamics coupled to DNA repair.与DNA修复耦合的染色质动力学
Epigenetics. 2009 Jan;4(1):31-42. doi: 10.4161/epi.4.1.7733. Epub 2009 Jan 31.
9
The histone shuffle: histone chaperones in an energetic dance.组蛋白洗牌:组蛋白伴侣在能量舞蹈中。
Trends Biochem Sci. 2010 Sep;35(9):476-89. doi: 10.1016/j.tibs.2010.04.001. Epub 2010 May 3.
10
Chromatin and the DNA damage response: the cancer connection.染色质与 DNA 损伤反应:癌症关联。
Mol Oncol. 2011 Aug;5(4):349-67. doi: 10.1016/j.molonc.2011.06.001. Epub 2011 Jul 3.

引用本文的文献

2
Hypoxic reactivation of Kaposi's sarcoma associated herpesvirus.卡波西肉瘤相关疱疹病毒的低氧再激活
Cell Insight. 2024 Sep 7;3(6):100200. doi: 10.1016/j.cellin.2024.100200. eCollection 2024 Dec.

本文引用的文献

8
The replisome guides nucleosome assembly during DNA replication.复制体在DNA复制过程中指导核小体组装。
Cell Biosci. 2020 Mar 12;10:37. doi: 10.1186/s13578-020-00398-z. eCollection 2020.
9
Chromatin remodeling and mismatch repair: Access and excision.染色质重塑和错配修复:进入和切除。
DNA Repair (Amst). 2020 Jan;85:102733. doi: 10.1016/j.dnarep.2019.102733. Epub 2019 Oct 17.
10
Histone deposition promotes recombination-dependent replication at arrested forks.组蛋白沉积促进停滞叉处依赖重组的复制。
PLoS Genet. 2019 Oct 4;15(10):e1008441. doi: 10.1371/journal.pgen.1008441. eCollection 2019 Oct.

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验