Department of Biochemistry and Molecular Genetics, University of Colorado School of Medicine, Aurora, CO 80045, USA.
Cell. 2010 Jan 22;140(2):183-95. doi: 10.1016/j.cell.2010.01.004.
Nuclear DNA is tightly packaged into chromatin, which profoundly influences DNA replication, transcription, repair, and recombination. The extensive interactions between the basic histone proteins and acidic DNA make the nucleosomal unit of chromatin a highly stable entity. For the cellular machinery to access the DNA, the chromatin must be unwound and the DNA cleared of histone proteins. Conversely, the DNA has to be repackaged into chromatin afterward. This review focuses on the roles of the histone chaperones in assembling and disassembling chromatin during the processes of DNA replication and repair.
核 DNA 被紧密地包装成染色质，这深刻地影响着 DNA 的复制、转录、修复和重组。碱性组蛋白与酸性 DNA 之间的广泛相互作用使得染色质的核小体单元成为一种高度稳定的实体。为了让细胞机器能够访问 DNA，染色质必须解旋，组蛋白必须从 DNA 上被清除。相反，在这之后，DNA 必须重新包装成染色质。这篇综述主要关注了组蛋白伴侣在 DNA 复制和修复过程中组装和解组装染色质的作用。
