Endurance Performance Research Group (GEDAE-USP), School of Physical Education and Sport, University of São Paulo, São Paulo, SP, Brazil; Sports Center, Department of Physical Education, Federal University of Santa Catarina, Florianopolis, SC, Brazil.
School of Kinesiology, University of British Columbia, Vancouver, BC, Canada; Barcelona Institute for Global Health (ISGlobal), Barcelona, Spain; Universitat de Pompeu Fabra (UPF), Barcelona, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain.
Sci Total Environ. 2022 Feb 25;809:151094. doi: 10.1016/j.scitotenv.2021.151094. Epub 2021 Oct 22.
High-intensity interval exercise (HIIE) is an effective non-pharmacological tool for improving physiological responses related to health. When HIIE is performed in urban centers, however, the exerciser is exposed to traffic-related air pollution (TRAP), which is associated with metabolic, anti-inflammatory imbalance and cardiovascular diseases. This paradoxical combination has the potential for conflicting health effects. Thus, the aim of this study was to determine the effects of HIIE performed in TRAP exposure on serum cytokines, non-target metabolomics and cardiovascular parameters. Fifteen participants performed HIIE in a chamber capable to deliver filtered air (FA condition) or non-filtered air (TRAP condition) from a polluted site adjacent to the exposure chamber. Non-target blood serum metabolomics, blood serum cytokines and blood pressure analyses were collected in both FA and TRAP conditions at baseline, 10 min after exercise, and 1 h after exercise. The TRAP increased IL-6 concentration by 1.7 times 1 h after exercise (p < 0.01) and did not change the anti-inflammatory balance (IL-10/TNF-α ratio). In contrast, FA led to an increase in IL-10 and IL-10/TNF-α ratio (p < 0.01), by 2.1 and 2.3 times, respectively. The enrichment analysis showed incomplete fatty acid metabolism under the TRAP condition (p < 0.05) 10 min after exercise. There was also an overactivity of ketone body metabolism (p < 0.05) at 10 min and at 1 h after exercise with TRAP. Exercise-induced acute decrease in systolic blood pressure (SBP) was not observed at 10 min and impaired at 1 h after exercise (p < 0.05). These findings reveal that TRAP potentially attenuates health benefits often related to HIIE. For instance, the anti-inflammatory balance was impaired, accompanied by accumulation of metabolites related to energy supply and reduction to exercise-induced decrease in SBP.
高强度间歇训练（HIIE）是改善与健康相关的生理反应的有效非药物工具。然而，当 HIIE 在城市中心进行时，锻炼者会暴露在与交通相关的空气污染（TRAP）中，而这种空气污染与代谢、抗炎失衡和心血管疾病有关。这种矛盾的组合有可能产生冲突的健康影响。因此，本研究旨在确定在 TRAP 暴露下进行 HIIE 对血清细胞因子、非靶向代谢组学和心血管参数的影响。15 名参与者在一个能够提供过滤空气（FA 条件）或来自暴露室附近污染地点的未过滤空气（TRAP 条件）的室中进行 HIIE。在 FA 和 TRAP 条件下，在基线、运动后 10 分钟和运动后 1 小时收集非靶向血清代谢组学、血清细胞因子和血压分析。TRAP 在运动后 1 小时使 IL-6 浓度增加 1.7 倍（p<0.01），并且没有改变抗炎平衡（IL-10/TNF-α 比值）。相比之下，FA 导致 IL-10 和 IL-10/TNF-α 比值分别增加 2.1 倍和 2.3 倍（p<0.01）。富集分析显示，运动后 10 分钟 TRAP 条件下不完全的脂肪酸代谢（p<0.05）。在运动后 10 分钟和 1 小时，酮体代谢也过度活跃（p<0.05）。运动引起的收缩压（SBP）急性下降在运动后 10 分钟和 1 小时均未观察到（p<0.05）。这些发现表明，TRAP 可能会削弱通常与 HIIE 相关的健康益处。例如，抗炎平衡受损，伴随着与能量供应相关的代谢物积累和运动引起的 SBP 下降减少。
