Jilin Provincial Key Laboratory on Molecular and Chemical Genetic, The Second Hospital of Jilin University, Changchun, China; Hand Surgery Department, The Second Hospital of Jilin University, Changchun, Jilin Province, China.
Jilin Provincial Key Laboratory on Molecular and Chemical Genetic, The Second Hospital of Jilin University, Changchun, China.
Pharmacol Res. 2021 Dec;174:105957. doi: 10.1016/j.phrs.2021.105957. Epub 2021 Oct 22.
Patients with neuropathic pain induced by nerve injury usually present with co-morbid affective changes, such as depression. Neuroglia was reported to play an important role in the development and maintenance of neuropathic pain both centrally and peripherally. Meanwhile, there have been studies showing that neuroglia participated in the development of depression. However, the specific role of neuroglia in neuropathic pain and depression has not been reviewed comprehensively. Therefore, we summarized the recent findings on the role of neuroglia in neuropathic pain and depression. Based on this review, we found a bridge-like role of neuroglia in neuropathic pain co-morbid with depression. This review may provide therapeutic implications in the treatment of neuropathic pain and offer potential help in the studies of mechanisms in the future.
神经损伤引起的神经性疼痛患者通常伴有并存的情感变化，如抑郁。神经胶质在中枢和外周神经系统中对神经性疼痛的发展和维持起着重要作用。同时，有研究表明神经胶质参与了抑郁的发展。然而，神经胶质在神经性疼痛和抑郁中的具体作用尚未得到全面综述。因此，我们总结了神经胶质在神经性疼痛和抑郁中的作用的最新发现。基于这篇综述，我们发现神经胶质在神经性疼痛伴发抑郁中起着桥梁作用。这篇综述可能为神经性疼痛的治疗提供治疗意义，并为未来的机制研究提供潜在帮助。
