Department of Orthopaedics, Lanzhou University Second Hospital, Cuiyingmen, Lanzhou, Gansu, #82, China.
Orthopaedics Key Laboratory of Gansu Province, Lanzhou, Gansu, China.
Arch Osteoporos. 2021 Oct 23;16(1):157. doi: 10.1007/s11657-021-01025-1.
This research is a cross-sectional study based on the participants aged 50 years and older from National Health and Nutrition Examination Survey (NHANES) database. Poor sleep patterns were associated with lower bone mineral density (BMD) and a higher risk of osteoporosis, especially among older individuals or females.
Accumulated evidence demonstrates that sleep duration, which is one aspect of sleep pattern, is associated with the risk of osteoporosis. However, the related studies on the association between sleep patterns and the risk of osteoporosis were limited. Therefore, this research aims to investigate the association of sleep patterns with BMD and the risk of osteoporosis among individuals aged 50 years and older.
Participants aged ≥ 50 years from the NHANES database were included in the present study. The diagnosis of osteoporosis was based on the results of BMD testing. Moreover, all the participants were divided into different sleep pattern groups according to nocturnal sleep duration and bedtime. In addition, this study used multivariate linear regression models to evaluate the association between sleep patterns and BMD and exploited multiple logistic regression models to investigate the odds ratios (ORs) for osteoporosis.
Finally, 1,865 individuals (non-osteoporosis: N = 1,713; osteoporosis: N = 152) aged over 50 years old with complete data were analyzed. The results of multivariate linear regression models showed that individuals with normal sleep duration/later bedtime or long sleep duration/later bedtime had lower femoral BMD than those with normal sleep duration/usual bedtime. Moreover, subjects with long sleep duration/later bedtime had a higher risk of osteoporosis compared with those with normal sleep duration/usual bedtime. In addition, subgroup analyses revealed the association of sleep patterns with BMD and the risk of osteoporosis appeared to be more pronounced among individuals aged ≥ 65 years or females.
This study demonstrated that sleep patterns are associated with BMD and the risk of osteoporosis. Poor sleep patterns contribute to decreased bone mass and the increased risk of osteoporosis. Therefore, a healthy sleep pattern is favorable for the prevention of osteoporosis.
本研究基于国家健康与营养调查（NHANES）数据库中年龄在 50 岁及以上的参与者，属于横断面研究。较差的睡眠模式与较低的骨密度（BMD）和更高的骨质疏松症风险相关，尤其是在年龄较大或女性中。
越来越多的证据表明，睡眠时长是睡眠模式的一个方面，与骨质疏松症的风险相关。然而，关于睡眠模式与骨质疏松症风险之间关联的相关研究有限。因此，本研究旨在调查睡眠模式与 50 岁及以上人群的 BMD 和骨质疏松症风险之间的关联。
本研究纳入了 NHANES 数据库中年龄≥50 岁的参与者。骨质疏松症的诊断基于 BMD 检测结果。此外，所有参与者根据夜间睡眠时间和就寝时间分为不同的睡眠模式组。此外，本研究使用多元线性回归模型评估睡眠模式与 BMD 之间的关联，并利用多因素逻辑回归模型探讨骨质疏松症的比值比（OR）。
最终分析了 1865 名年龄在 50 岁以上且数据完整的个体（非骨质疏松症：N=1713；骨质疏松症：N=152）。多元线性回归模型的结果表明，与正常睡眠时间/通常就寝时间或长睡眠时间/通常就寝时间的个体相比，正常睡眠时间/较晚就寝时间或长睡眠时间/较晚就寝时间的个体股骨 BMD 较低。此外，与正常睡眠时间/通常就寝时间的个体相比，长睡眠时间/较晚就寝时间的个体患骨质疏松症的风险更高。此外，亚组分析表明，睡眠模式与 BMD 和骨质疏松症风险之间的关联在年龄≥65 岁或女性中更为明显。
本研究表明，睡眠模式与 BMD 和骨质疏松症风险相关。较差的睡眠模式会导致骨量减少和骨质疏松症风险增加。因此，健康的睡眠模式有利于预防骨质疏松症。
