Nakajima Hiroki, Nishioka Yuichi, Tamaki Yuko, Kamitani Fumika, Kurematsu Yukako, Okada Sadanori, Myojin Tomoya, Noda Tatsuya, Imamura Tomoaki, Takahashi Yutaka
Department of Diabetes and Endocrinology, Nara Medical University, Nara 634-8521, Japan.
Department of Public Health, Health Management and Policy, Nara Medical University, Nara 634-8521, Japan.
J Endocr Soc. 2025 Aug 28;9(9):bvaf127. doi: 10.1210/jendso/bvaf127. eCollection 2025 Sep.
Lifestyle habits, such as exercise, alcohol consumption, and smoking, are known to be closely associated with the risk of osteoporotic fracture. However, little is known regarding the association between osteoporotic fracture and dietary habits such as skipping breakfast and having a late dinner.
This study aimed to examine the association between lifestyle habits, including diet, and the risk of osteoporotic fracture.
Individuals aged 20 years or older were enrolled using the results of lifestyle questionnaires in health checkup data and the DeSC database, a Japanese claims database. Outcome was defined as the diagnosis of osteoporotic fracture (hip, distal forearm, vertebral, and humeral fractures). A Cox proportional-hazards model was used to calculate the association between osteoporotic fracture risk and lifestyle, adjusting for conventional risk factors. In the lifestyle questionnaires, those who answered "yes" to each question were compared to those who answered "no."
Altogether, 927 130 participants were included, with a median follow-up duration of 2.6 years. The adjusted hazard ratios (95% CI) for lifestyle factors of smoking, daily alcohol consumption, exercise habits, fast gait speed, enough sleep, skipping breakfast, and late dinner were 1.11 (1.06-1.17), 0.91 (0.88-0.95), 0.99 (0.97-1.02), 0.84 (0.82-0.86), 0.95 (0.93-0.98), 1.18 (1.12-1.23), and 1.08 (1.04-1.12), respectively.
Our study is the first to demonstrate that skipping breakfast and having a late dinner are independently associated with a higher risk of osteoporotic fracture, using a large health checkup cohort.
众所周知，生活方式习惯，如运动、饮酒和吸烟，与骨质疏松性骨折的风险密切相关。然而，关于骨质疏松性骨折与不吃早餐和晚餐过晚等饮食习惯之间的关联，人们了解甚少。
本研究旨在探讨包括饮食在内的生活方式习惯与骨质疏松性骨折风险之间的关联。
利用健康体检数据中的生活方式问卷结果和日本索赔数据库DeSC数据库，纳入20岁及以上的个体。结局定义为骨质疏松性骨折（髋部、前臂远端、脊椎和肱骨骨折）的诊断。采用Cox比例风险模型计算骨质疏松性骨折风险与生活方式之间的关联，并对传统风险因素进行调整。在生活方式问卷中，将对每个问题回答“是”的人与回答“否”的人进行比较。
总共纳入了927130名参与者，中位随访时间为2.6年。吸烟、每日饮酒、运动习惯、步速快、睡眠充足、不吃早餐和晚餐过晚等生活方式因素的调整后风险比（95%CI）分别为1.11（1.06 - 1.17）、0.91（0.88 - 0.95）、0.99（0.97 - 1.02）、0.84（0.82 - 0.86）、0.95（0.93 - 0.98）、1.18（1.12 - 1.23）和1.08（1.04 - 1.12）。
我们的研究首次表明，使用大型健康体检队列研究发现，不吃早餐和晚餐过晚与骨质疏松性骨折风险较高独立相关。
