Departament of Clinical Analyses and Biomedicine, Universidade Estadual de Maringá, Maringá, Paraná, CEP, 87020-900, Brazil.
Departament of Pharmacy and Science, Faculdade Integrado de Campo Mourão, Campo Mourão, Paraná, CEP, 87300-970, Brazil.
Future Microbiol. 2021 Nov;16:1277-1288. doi: 10.2217/fmb-2021-0048. Epub 2021 Oct 25.
Trichosporonosis infections have been increasing worldwide. Providing adequate treatment for these infections remains a challenge. This scoping review contains information about potential antifungals to treat this pathology. Using online databases, we found 76 articles published between 2010 and 2020 related to this topic. Classic antifungals, molecules and biomolecules, repositioned drugs and natural products have been tested against species of . Experimental research has lacked depth or was limited to and tests, so there are no promising new candidates for the clinical treatment of patients with trichosporonosis. Furthermore, most studies did not present appropriate scientific criteria for drug tests, compromising their quality.
曲霉菌病感染在全球范围内呈上升趋势。为这些感染提供充分的治疗仍然是一个挑战。本范围综述包含了治疗这种病理学的潜在抗真菌药物的信息。使用在线数据库,我们找到了 76 篇发表于 2010 年至 2020 年之间的与该主题相关的文章。经典抗真菌药、分子和生物分子、重新定位药物和天然产物已针对 进行了测试。实验研究缺乏深度或仅限于 和 测试,因此,对于曲霉菌病患者的临床治疗,没有有前途的新药候选物。此外,大多数研究没有为药物测试提供适当的科学标准,从而降低了其质量。