Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA; Department of Transfusion Medicine, New York-Presbyterian Hospital, New York, NY, USA.
Butterworth Blood Bank, Department of Pathology, Michigan Pathology Specialists, Spectrum Health Hospitals, Grand Rapids, MI, USA.
Clin Lab Med. 2021 Dec;41(4):647-657. doi: 10.1016/j.cll.2021.07.007. Epub 2021 Sep 29.
Neutrophils are an integral component of the innate immune system and key regulators of cell-mediated defense against bacterial and fungal pathogens. The potential of granulocyte transfusions has been investigated to temporarily replenish innate immune function to prevent and/or treat infections in patients with severe neutropenia or neutrophil dysfunction. However, evidence has been largely theoretical, experimental, and/or inconclusive. Clinical efficacy has yet to be confirmed by large-scale randomized controlled clinical trials. Performing such trials has been hampered by low granulocyte collection yield and poor patient accrual. We provide a practical summary of the current literature surrounding the practice of granulocyte transfusion.
中性粒细胞是先天免疫系统的重要组成部分，也是细胞介导的防御细菌和真菌病原体的关键调节剂。已经研究了粒细胞输注的潜力，以暂时补充先天免疫功能，预防和/或治疗严重中性粒细胞减少症或中性粒细胞功能障碍患者的感染。然而，证据在很大程度上是理论的、实验性的和/或不确定的。临床疗效尚未通过大规模随机对照临床试验得到证实。由于粒细胞采集产量低和患者入组困难，此类试验的开展受到了阻碍。我们对粒细胞输注实践的现有文献进行了实用总结。
