COVID-19 病死率与阿尔茨海默病
COVID-19 Case Fatality and Alzheimer's Disease.
机构信息
Department of Neurology, University of Iowa, Iowa City, IA, USA.
Department of Psychiatry, University of Iowa, Iowa City, IA, USA.
出版信息
J Alzheimers Dis. 2021;84(4):1447-1452. doi: 10.3233/JAD-215161.
Abstract
Previous studies have identified dementia as a risk factor for death from coronavirus disease 2019 (COVID-19). However, it is unclear whether Alzheimer's disease (AD) is an independent risk factor for COVID-19 case fatality rate. In a retrospective cohort study, we identified 387,841 COVID-19 patients through TriNetX. After adjusting for demographics and comorbidities, we found that AD patients had higher odds of dying from COVID-19 compared to patients without AD (Odds Ratio: 1.20, 95%confidence interval: 1.09-1.32, p < 0.001). Interestingly, we did not observe increased mortality from COVID-19 among patients with vascular dementia. These data are relevant to the evolving COVID-19 pandemic.
摘要
先前的研究已经确定痴呆是 2019 年冠状病毒病（COVID-19）死亡的一个风险因素。然而，尚不清楚阿尔茨海默病（AD）是否是 COVID-19 病死率的一个独立风险因素。在一项回顾性队列研究中，我们通过 TriNetX 确定了 387841 例 COVID-19 患者。在调整了人口统计学和合并症后，我们发现与没有 AD 的患者相比，AD 患者死于 COVID-19 的几率更高（比值比：1.20，95%置信区间：1.09-1.32，p<0.001）。有趣的是，我们没有观察到血管性痴呆患者 COVID-19 死亡率的增加。这些数据与不断演变的 COVID-19 大流行有关。
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2
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3
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