聚山梨醇酯80与多粘菌素B对铜绿假单胞菌NCTC 6750原生质球的协同作用。

Additivity of action between polysorbate 80 and polymyxin B towards spheroplasts of Pseudomonas aeruginosa NCTC 6750.

作者信息

Brown M R, Geaton E M, Gilbert P

出版信息

J Pharm Pharmacol. 1979 Mar;31(3):168-70. doi: 10.1111/j.2042-7158.1979.tb13463.x.

DOI:10.1111/j.2042-7158.1979.tb13463.x

Abstract

When polymyxin B and polysorbate 80 were used together against spheroplasts of Pseudomonas aeruginosa, the activities were found to be additive. These substances have previously been reported to act synergistically against P. aeruginosa, but little or no intrinsic activity towards intact cells has been attributed to polysorbate 80. We suggest that in addition to enhancing polymyxin B penetration to the cytoplasmic membrane, polysorbate 80 may also act as an antimicrobial agent when polymyxin-induced damage to the outer membrane facilitates the surfactant's passage through the cell envelope.

摘要

当多粘菌素B和聚山梨醇酯80联合用于对抗铜绿假单胞菌原生质球时,发现二者活性具有相加性。此前有报道称这些物质对铜绿假单胞菌具有协同作用,但聚山梨醇酯80对完整细胞几乎没有或基本上没有内在活性。我们认为, 除增强多粘菌素B渗透到细胞质膜的能力外,当多粘菌素对外膜造成的损伤促进表面活性剂穿过细胞包膜时,聚山梨醇酯80可能还充当杀菌剂。