单一必需氨基酸饥饿诱导HL-60分化，而非蛋白质合成抑制剂诱导。
Induction of HL-60 differentiation by starvation for a single essential amino acid but not by protein synthesis inhibitors.
作者信息
Pilz R B, Van den Berghe G, Boss G R
出版信息
J Clin Invest. 1987 Mar;79(3):1006-9. doi: 10.1172/JCI112867.
Abstract
Starvation for a single essential amino acid induced differentiation of the human promyelocytic leukemia line HL-60 into morphologically and functionally mature granulocytes. Differentiation occurred when protein synthesis was inhibited up to 90% but was not simply secondary to growth arrest or protein synthesis inhibition, because neither glucose starvation nor treatment with protein synthesis inhibitors induced differentiation. Induction of differentiation by an aminoacyl tRNA synthetase inhibitor and the effect of cycloheximide and puromycin on amino acid-starved cells suggested an important regulatory role of tRNA molecules during differentiation.
摘要
单一必需氨基酸饥饿可诱导人早幼粒细胞白血病细胞系HL-60分化为形态和功能成熟的粒细胞。当蛋白质合成被抑制高达90%时发生分化，但这并非仅仅是生长停滞或蛋白质合成抑制的继发结果，因为葡萄糖饥饿和蛋白质合成抑制剂处理均未诱导分化。氨酰tRNA合成酶抑制剂诱导分化以及环己酰亚胺和嘌呤霉素对氨基酸饥饿细胞的作用表明，tRNA分子在分化过程中具有重要的调节作用。
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本文引用的文献
1
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2
Alterations in tRNA isoaccepting species during erythroid differentiation of the Friend leukemia cell.弗氏白血病细胞红系分化过程中同功tRNA种类的变化
Nucleic Acids Res. 1980 Aug 11;8(15):3467-80. doi: 10.1093/nar/8.15.3467.
3
Alterations of transcription and translation in HeLa cells exposed to amino acid analogs.暴露于氨基酸类似物的HeLa细胞中转录和翻译的改变。
Mol Cell Biol. 1984 Jun;4(6):1063-72. doi: 10.1128/mcb.4.6.1063-1072.1984.
4
Decreased purine synthesis during amino acid starvation of human lymphoblasts.人淋巴母细胞氨基酸饥饿期间嘌呤合成减少。
J Biol Chem. 1982 Apr 25;257(8):4242-7.
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Annu Rev Biochem. 1983;52:441-66. doi: 10.1146/annurev.bi.52.070183.002301.
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Ribonucleic acid biosynthesis of human cells during amino acid deprivation.氨基酸缺乏时人类细胞的核糖核酸生物合成
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