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一名新冠肺炎年轻成人患者的无症状性横纹肌溶解症

Asymptomatic Rhabdomyolysis in a Young Adult With COVID-19.

作者信息

Farouji Abdelhadi, Hellou Rabea, Peretz Asaf

机构信息

Internal Medicine, Assuta Ashdod Medical Center, Ben-Gurion University of the Negev, Ashdod, ISR.

出版信息

Cureus. 2021 Sep 17;13(9):e18039. doi: 10.7759/cureus.18039. eCollection 2021 Sep.

DOI:10.7759/cureus.18039
PMID:34692275
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8523336/
Abstract

The novel coronavirus disease 2019 (COVID-19) is an ongoing pandemic. Although COVID-19 is frequently associated with respiratory symptoms and complications, multiple extrapulmonary manifestations have been identified since the beginning of the pandemic. Rhabdomyolysis has been described in the literature as one of the extrapulmonary manifestations of COVID-19. Herein, we describe a 21-year-old male patient who presented with cough and fever secondary to COVID-19 confirmed by positive reverse-transcription polymerase chain reaction (RT-PCR) for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The patient presented with an extremely elevated creatinine kinase (CK) of 53,886 U/L (normal 10-170) without any classical symptoms of rhabdomyolysis or deterioration in his kidney function. He was successfully managed with aggressive intravenous fluids. The aim of reporting this case is to highlight the importance of including total CK in the initial evaluation of COVID-19 patients.

摘要

2019年新型冠状病毒病(COVID-19)是一场持续的大流行病。尽管COVID-19常与呼吸道症状及并发症相关,但自疫情开始以来已发现多种肺外表现。横纹肌溶解症在文献中被描述为COVID-19的肺外表现之一。在此,我们描述一名21岁男性患者,他因严重急性呼吸综合征冠状病毒2(SARS-CoV-2)逆转录聚合酶链反应(RT-PCR)呈阳性而确诊为COVID-19,继发咳嗽和发热。该患者肌酸激酶(CK)极度升高至53886 U/L(正常范围10 - 170),却无任何横纹肌溶解的典型症状或肾功能恶化。通过积极静脉补液,他得到了成功治疗。报告此病例的目的是强调在COVID-19患者初始评估中纳入总CK的重要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b84/8523336/3f2802d487f3/cureus-0013-00000018039-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b84/8523336/6839577e4ab6/cureus-0013-00000018039-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b84/8523336/ac9156fb160a/cureus-0013-00000018039-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b84/8523336/3f2802d487f3/cureus-0013-00000018039-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b84/8523336/6839577e4ab6/cureus-0013-00000018039-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b84/8523336/ac9156fb160a/cureus-0013-00000018039-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b84/8523336/3f2802d487f3/cureus-0013-00000018039-i03.jpg

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引用本文的文献

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Rhabdomyolysis secondary to COVID-19 infection and vaccination: a review of literature.新型冠状病毒肺炎感染及疫苗接种继发横纹肌溶解症:文献综述
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本文引用的文献

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Adolescent COVID-19-Associated Fatal Rhabdomyolysis.青少年 COVID-19 相关致死性横纹肌溶解症。
J Prim Care Community Health. 2020 Jan-Dec;11:2150132720985641. doi: 10.1177/2150132720985641.
2
Rhabdomyolysis and Acute Kidney Injury as Leading COVID-19 Presentation in an Adolescent.横纹肌溶解症和急性肾损伤是青少年 COVID-19 的主要表现。
Pediatr Infect Dis J. 2020 Oct;39(10):e314-e315. doi: 10.1097/INF.0000000000002853.
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Coronavirus Disease 2019-Induced Rhabdomyolysis.2019冠状病毒病所致横纹肌溶解症
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Rhabdomyolysis and Acute Renal Failure in an Adolescent With Coronavirus Disease 2019.横纹肌溶解症和急性肾衰与 2019 年冠状病毒病。
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Rhabdomyolysis as an initial presentation in a patient diagnosed with COVID-19.横纹肌溶解症作为确诊为新型冠状病毒肺炎患者的首发表现。
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Extrapulmonary and atypical clinical presentations of COVID-19.COVID-19 的肺外和非典型临床表现。
J Med Virol. 2020 Nov;92(11):2458-2464. doi: 10.1002/jmv.26157. Epub 2020 Jun 29.
8
Pediatric COVID-19-associated rhabdomyolysis: a case report.儿童 COVID-19 相关横纹肌溶解症:病例报告。
Pediatr Nephrol. 2020 Aug;35(8):1517-1520. doi: 10.1007/s00467-020-04617-0. Epub 2020 May 23.
9
Weakness and elevated creatinine kinase as the initial presentation of coronavirus disease 2019 (COVID-19).以乏力和肌酸激酶升高为首发表现的 2019 冠状病毒病(COVID-19)。
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10
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Cureus. 2020 Apr 6;12(4):e7561. doi: 10.7759/cureus.7561.