甲氨蝶呤诱发的败血症伴严重全血细胞减少和弥漫性皮肤溃疡性病变
Methotrexate-Induced Septicemia With Severe Pancytopenia and Diffuse Cutaneous Ulcerative Lesions.
作者信息
Tiewsoh Iadarilang, Dey Biswajit, Chhangte Mary, Lyngdoh Monaliza, Sathees Varsha
机构信息
General Medicine, North Eastern Indira Gandhi Regional Institute of Health and Medical Sciences, Shillong, IND.
Pathology, North Eastern Indira Gandhi Regional Institute of Health and Medical Sciences, Shillong, IND.
出版信息
Cureus. 2021 Sep 17;13(9):e18069. doi: 10.7759/cureus.18069. eCollection 2021 Sep.
Methotrexate, a folate antimetabolite and one of the first few anti-neoplastic drugs, is now a commonly used drug in the treatment of many inflammatory disorders ranging from diseases like rheumatoid arthritis to psoriasis. The life-threatening toxicity of methotrexate in inflammatory diseases is not commonly encountered. Here we report a case of life-threatening multiorgan failure from methotrexate toxicity, which was given for skin lesions suspected to be psoriasis.
甲氨蝶呤是一种叶酸抗代谢物，也是最早的几种抗肿瘤药物之一，目前是治疗从类风湿性关节炎到牛皮癣等多种炎症性疾病的常用药物。甲氨蝶呤在炎症性疾病中危及生命的毒性并不常见。在此，我们报告一例因甲氨蝶呤毒性导致危及生命的多器官功能衰竭病例，该患者因疑似牛皮癣的皮肤病变而接受了甲氨蝶呤治疗。
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