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新冠后毛霉菌病的多样性与转归:一例报告

The diversity and outcome of post-covid mucormycosis: A case report.

作者信息

Saad Reem Hassan, Mobarak Fahmy A

机构信息

Department of Cranio-Maxillofacial Surgery, Nasser Institute for Research and Treatment, Cairo, Egypt.

Head of Department of Cranio-Maxillofacial Surgery, Nasser Institute for Research and Treatment, Cairo, Egypt.

出版信息

Int J Surg Case Rep. 2021 Nov;88:106522. doi: 10.1016/j.ijscr.2021.106522. Epub 2021 Oct 18.

Abstract

INTRODUCTION AND IMPORTANCE

The impact of Covid-19 pandemic on the incidence and pattern of Mucormycosis (the black fungus), has increased sharply and is featured as an epidemic within a pandemic. The majority of cases were detected at late stages, which decreases the chances of survival.

CASE PRESENTATION

The authors present a case of an immunocompetent male patient diagnosed with left orbital apex syndrome post covid-19 infection, which necessitated orbital exenteration. He was later hospitalized in a quarantine facility and an area of skin breakdown on his left cheek was noted and surgical debridement performed. Later, He presented to our institution with left hemifacial skin loss, exposing the underlying diseased bone. A multidisciplinary team examined the patient clinically and radiographically, reaching a primitive diagnosis of secondary cutaneous Mucormycosis due to rhino-orbital Mucormycosis, with no cavernous sinus thrombosis nor cranial extension. Radical surgical and medical treatments were given and he had an uneventful recovery. Unfortunately, he died 5 days after the reconstructive surgery with Anterolateral Thigh (ALT) flap.

CLINICAL DISCUSSION

The dual effect of both covid-19 and its' associated Mucormycosis, predispose patients to increased risk of pressure injuries including Medical device related pressure injuries. Survivors of Mucormycosis are high-risk patients, and planning their reconstruction by free flaps is challenging. However, delayed reconstruction is recommended.

CONCLUSION

Early diagnosis and management of covid-19 associated Mucormycosis should be prioritized. Moreover, surgical debridement of necrotic tissues should not be delayed due to an unavailable or negative histopathology.

摘要

引言与重要性

新冠疫情对毛霉菌病(黑真菌病)的发病率和模式产生了急剧影响,其特征是在大流行中成为一种流行病。大多数病例在晚期才被发现,这降低了存活几率。

病例报告

作者报告一例免疫功能正常的男性患者,在新冠感染后被诊断为左眶尖综合征,这需要进行眶内容剜除术。他后来被收治于一家隔离设施,左脸颊出现皮肤破损区域,遂进行了手术清创。之后,他因左半侧面部皮肤缺损、深部患病骨骼暴露而就诊于我们的机构。一个多学科团队对该患者进行了临床和影像学检查,初步诊断为因鼻眶毛霉菌病导致的继发性皮肤毛霉菌病,无海绵窦血栓形成及颅内扩展。给予了根治性手术和药物治疗,他恢复顺利。不幸的是,在接受股前外侧(ALT)皮瓣重建手术后5天,他去世了。

临床讨论

新冠及其相关的毛霉菌病的双重影响,使患者发生压力性损伤(包括与医疗器械相关的压力性损伤)的风险增加。毛霉菌病幸存者是高危患者,通过游离皮瓣为他们规划重建手术具有挑战性。然而,建议延迟重建。

结论

应优先对新冠相关的毛霉菌病进行早期诊断和管理。此外,不应因组织病理学检查结果不可得或为阴性而延迟对坏死组织的手术清创。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/55ce/8554263/c0aef4b57581/gr1.jpg

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