趋化因子（C-X-C 基序）受体 2 C1208T 多态性对癌症易感性的影响。

Impacts of Chemokine (C-X-C Motif) Receptor 2 C1208T Polymorphism on Cancer Susceptibility.

机构信息

Department of Oncology, Affiliated Hospital of Jiangnan University, Hefeng Road 1000, Wuxi 214000, China.

Department of Urology, Changzhou No.2 People's Hospital, 29 Xinglong Road, Changzhou 213003, China.

出版信息

J Immunol Res. 2021 Oct 14;2021:8727924. doi: 10.1155/2021/8727924. eCollection 2021.

DOI:10.1155/2021/8727924

PMID:34692853

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8531794/

Abstract

BACKGROUND

The CXC chemokines belong to a unique family of cytokines that participates in the progression and development of many malignant tumors. Evidence for the relationship between chemokine (C-X-C motif) receptor 2 (CXCR2) C1208T polymorphism and susceptibility to cancer remains inconsistent.

METHODS

Odds ratios (ORs), 95% confidence intervals (CIs), and combined analysis were used to investigate the effect of CXCR2 variation on cancer risk. Gene Set Enrichment Analysis (GSEA) and enzyme-linked immunosorbent assay (ELISA) were also used to evaluate the expression of CXCR2 in prostate cancer (PCA).

RESULTS

Across 11 case-control studies, 4,909 cases and 5,884 controls were involved in the current analysis. Individuals with a TT genotype were associated with increased risk of digestive cancer, compared to those with a TC+CC genotype (OR = 1.16, 95%CI = 1.02-1.31, = 0.025). Individuals carrying the TT genotype had a 39% higher risk of urinary cancer than those carrying CC genotype (OR = 1.39, 95%CI = 1.04-1.87, = 0.025). Individuals with a TT genotype showed a 56% augmented breast cancer risk, compared to those with a CC genotype (OR = 1.56, 95%CI = 1.03-2.35, = 0.034). It was found that CXCR2 expression was downregulated in PCA. Compared with PCA subjects carrying the CC genotype, the expression of CXCR2 was decreased in patients with the TT genotype.

CONCLUSIONS

The CXCR2 C1208T variation was associated with elevated risk of urinary, breast, and digestive cancer. However, the C1208T polymorphism was correlated with attenuated risk of lung cancer.

摘要

背景

趋化因子（CXC 基序）受体 2（CXCR2）C1208T 多态性与癌症易感性之间的关系证据尚不一致。

方法

采用比值比（ORs）、95%置信区间（CIs）和合并分析来探讨 CXCR2 变异对癌症风险的影响。还使用基因集富集分析（GSEA）和酶联免疫吸附试验（ELISA）来评估 CXCR2 在前列腺癌（PCA）中的表达。

结果

在 11 项病例对照研究中，共纳入 4909 例病例和 5884 例对照。与 TC+CC 基因型相比，TT 基因型个体患消化癌的风险增加（OR=1.16，95%CI=1.02-1.31， =0.025）。携带 TT 基因型的个体患膀胱癌的风险比携带 CC 基因型的个体高 39%（OR=1.39，95%CI=1.04-1.87， =0.025）。与 CC 基因型相比，TT 基因型个体患乳腺癌的风险增加 56%（OR=1.56，95%CI=1.03-2.35， =0.034）。结果发现，CXCR2 在 PCA 中表达下调。与携带 CC 基因型的 PCA 患者相比，TT 基因型患者 CXCR2 的表达降低。