患有轻度认知障碍和痴呆症的巴西人的神经精神症状。
Neuropsychiatric symptoms in Brazilians with mild cognitive impairment and dementia.
作者信息
Wilson Robert S, Capuano Ana W, Sampaio Carolina, Leurgans Sue E, Barnes Lisa L, Farfel Jose M, Bennett David A
机构信息
Rush Alzheimer's Disease Center Rush University Medical Center Chicago Illinois USA.
Department of Neurological Sciences Rush University Medical Center Chicago Illinois USA.
出版信息
Alzheimers Dement (Amst). 2021 Oct 14;13(1):e12219. doi: 10.1002/dad2.12219. eCollection 2021.
INTRODUCTION
Knowledge is limited about behavioral and psychological symptoms of mild cognitive impairment (MCI) and dementia in racial and ethnic minorities.
METHODS
As part of the Pathology, Alzheimer's and Related Dementias Study (PARDoS), we interviewed knowledgeable informants of 2319 older Brazilian decedents (67% white, 11% black, 22% mixed) using the informant portion of the Clinical Dementia Rating Scale to classify MCI and dementia and the Neuropsychiatric Inventory to assess behavioral and psychological symptoms.
RESULTS
We identified four clusters of neuropsychiatric symptoms: agitation, affect/apathy, psychosis, and behavioral problems. On the Clinical Dementia Rating Scale, 1407 had no cognitive impairment, 180 had MCI, and 732 had dementia. Both MCI and dementia were associated with symptoms in each behavioral/psychological cluster (all 's < .001). There was little evidence of racial differences in the association of MCI and dementia with these neuropsychiatric symptoms.
CONCLUSION
MCI and dementia are associated with elevated behavioral and psychological symptoms in older black and white Brazilians.
引言
关于种族和少数民族中轻度认知障碍（MCI）和痴呆症的行为及心理症状，我们所知有限。
方法
作为病理学、阿尔茨海默病及相关痴呆症研究（PARDoS）的一部分，我们使用临床痴呆评定量表的知情人部分对2319名巴西老年死者（67%为白人，11%为黑人，22%为混血）的知情人进行了访谈，以对MCI和痴呆症进行分类，并使用神经精神量表评估行为和心理症状。
结果
我们确定了四类神经精神症状：激越、情感/淡漠、精神病和行为问题。在临床痴呆评定量表上，1407人无认知障碍，180人有MCI，732人有痴呆症。MCI和痴呆症均与各行为/心理症状群中的症状相关（所有P值均<0.001）。几乎没有证据表明MCI和痴呆症与这些神经精神症状之间的关联存在种族差异。
结论
在巴西老年黑人和白人中，MCI和痴呆症与行为和心理症状增加有关。
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