Vintimilla Raul, Hall James, King Kevin, Braskie Meredith N, Johnson Leigh, Yaffe Kristine, Toga Arthur W, O'Bryant Sid
University of North Texas Health Science Center Fort Worth Texas USA.
Barrow Neurological Institute Phoenix Arizona USA.
Alzheimers Dement (Amst). 2021 Oct 14;13(1):e12236. doi: 10.1002/dad2.12236. eCollection 2021.
The current project sought to evaluate the impact that white matter hyperintensities (WMH) have on executive function in cognitively normal Mexican Americans, an underserved population with onset and more rapid progression of dementia.
Data from 515 participants (360 female) enrolled in the Health and Aging Brain Study: Health Disparities project were analyzed. Participants underwent clinical evaluation, cognitive testing, and a brain MRI. Linear regression was used to predict the effect of total WMH volume on cognitive test scores. Age, sex, and education were entered as covariates.
Regression analysis showed that WMH volume significantly predicted executive function. WMH also predicted global cognition and attention scores, although not significantly after adjusting for age.
In this sample of cognitively normal Mexican Americans, we found that WMH volume was associated with lower scores in a measure of executive function, after accounting for age, sex, and education.
当前项目旨在评估白质高信号（WMH）对认知正常的墨西哥裔美国人执行功能的影响，这是一个在痴呆症发病和进展方面未得到充分研究且进展更快的人群。
对参与健康与衰老大脑研究：健康差异项目的515名参与者（360名女性）的数据进行了分析。参与者接受了临床评估、认知测试和脑部MRI检查。使用线性回归来预测总WMH体积对认知测试分数的影响。将年龄、性别和教育程度作为协变量纳入分析。
回归分析表明，WMH体积显著预测执行功能。WMH还预测了整体认知和注意力分数，尽管在调整年龄后不显著。
在这个认知正常的墨西哥裔美国人样本中，我们发现，在考虑年龄、性别和教育程度后，WMH体积与执行功能测量中的较低分数相关。
