Hossain Md Rezaul, Sarmin Monira, Rahman Hafizur, Shahrin Lubaba, Nyma Zannatun, Ahmed Tahmeed, Chisti Mohammod Jobayer
Nutrition and Clinical Services Division (NCSD), icddr,b.
Clinical Hematology & Cancer Biology, Laboratory Sciences & Services Division (LSSD), icddr,b.
Heliyon. 2021 Oct;7(10):e08229. doi: 10.1016/j.heliyon.2021.e08229. Epub 2021 Oct 20.
Coinfections are common in pandemics, however not in recorded patients with hemoglobinopathies. The Coronavirus Disease 2019 (COVID-19) pandemic struck Bangladesh at the beginning of March 2020, which is also an apt period for endemic Dengue fever in this monsoon region.
We report a 30-year-old man with hemoglobinopathies coinfected with Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and Dengue virus. Dengue virus was detected by Enzyme-linked Immunosorbent Assay (ELISA). COVID-19 was confirmed by Reverse-transcription Polymerase Chain Reaction (RT-PCR) and Hemoglobin Electrophoresis revealed heterozygous beta-thalassemia or thalassemia trait. The patient was treated successfully at Dhaka Hospital in icddr,b during COVID-19 emergency response with symptomatic supportive treatment for COVID-19 and appropriate fluid therapy for dengue fever in response to daily hematocrit level. The patient's repeated RT-PCR for COVID-19 on day-21 became negative. For thalassemia, the patient was advised to have genetic counseling and family screening on discharge.
The possibility of coinfection between COVID-19 and Dengue fever may be considered in a COVID-19 patient with unremitting fever especially in an area where Dengue fever is epidemic that may further help to attain appropriate management of the patient.
合并感染在大流行中很常见，但在有血红蛋白病记录的患者中并非如此。2019年冠状病毒病（COVID-19）大流行于2020年3月初袭击了孟加拉国，而这个季风地区也是登革热地方病的高发期。
我们报告了一名30岁患有血红蛋白病的男性，同时感染了严重急性呼吸综合征冠状病毒2（SARS-CoV-2）和登革热病毒。通过酶联免疫吸附测定（ELISA）检测到登革热病毒。通过逆转录聚合酶链反应（RT-PCR）确诊了COVID-19，血红蛋白电泳显示为杂合子β地中海贫血或地中海贫血特征。在COVID-19应急响应期间，该患者在达卡医院icddr,b接受了成功治疗，针对COVID-19进行了对症支持治疗，并根据每日血细胞比容水平对登革热进行了适当的液体治疗。患者在第21天重复进行的COVID-19 RT-PCR检测结果为阴性。对于地中海贫血，建议患者出院后进行遗传咨询和家庭筛查。
对于持续发热的COVID-19患者，尤其是在登革热流行地区，应考虑COVID-19与登革热合并感染的可能性，这可能有助于对患者进行适当的管理。
