Soto Celia A, Lo Celso Cristina, Purton Louise E, Frisch Benjamin J
Department of Pathology University of Rochester Medical Center Rochester New York USA.
Department of Life Sciences Imperial College London London UK.
JBMR Plus. 2021 Jun 3;5(10):e10516. doi: 10.1002/jbm4.10516. eCollection 2021 Oct.
The bone marrow microenvironment (BMME) regulates hematopoiesis through a complex network of cellular and molecular components. Hematologic malignancies reside within, and extensively interact with, the same BMME. These interactions consequently alter both malignant and benign hematopoiesis in multiple ways, and can encompass initiation of malignancy, support of malignant progression, resistance to chemotherapy, and loss of normal hematopoiesis. Herein, we will review supporting studies for interactions of the BMME with hematologic malignancies and discuss challenges still facing this exciting field of research. © 2021 The Authors. published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research.
骨髓微环境（BMME）通过细胞和分子成分的复杂网络调节造血作用。血液系统恶性肿瘤存在于相同的骨髓微环境中，并与之广泛相互作用。这些相互作用进而以多种方式改变恶性和良性造血作用，可能包括恶性肿瘤的起始、恶性进展的支持、化疗耐药性以及正常造血作用的丧失。在此，我们将综述支持骨髓微环境与血液系统恶性肿瘤相互作用的研究，并讨论这个令人兴奋的研究领域仍面临的挑战。© 2021作者。由Wiley Periodicals LLC代表美国骨与矿物质研究学会出版。
