Department of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Center for Cancer and Blood Disorders, Children's Hospital Colorado, Aurora, CO, USA.
Nat Cancer. 2020 Oct;1(10):939-940. doi: 10.1038/s43018-020-00127-y. Epub 2020 Oct 12.
Effective methods for treating retinoblastoma while preserving vision are an unmet clinical need. Subretinal delivery of a hydrogel containing T cells that secrete the cytokine IL-15 and express a chimeric antigen receptor directed at the ganglioside protein GD2 completely controls retinoblastoma in immunocompromised mice, with no obvious damage to the surrounding retina.
治疗视网膜母细胞瘤同时保留视力的有效方法是未满足的临床需求。将含有分泌细胞因子 IL-15 的 T 细胞的水凝胶递送至视网膜下，可完全控制免疫功能低下的小鼠中的视网膜母细胞瘤，同时对周围视网膜没有明显损伤，该水凝胶表达一种针对神经节苷脂蛋白 GD2 的嵌合抗原受体。
