Fatma Homa, Siddique Hifzur R, Maurya Santosh K
Molecular Cancer Genetics & Translational Research Lab, Section of Genetics, Department of Zoology, Aligarh Muslim University, Aligarh, Uttar Pradesh, 202002, India.
Epigenomics. 2021 Dec;13(23):1885-1900. doi: 10.2217/epi-2021-0228. Epub 2021 Oct 25.
The transcription factor NANOG regulates self-renewal and pluripotency in embryonic cells, and its downregulation leads to cell differentiation. Recent studies have linked upregulation of in various cancers and the regulation of expression of different molecules, and , to induce proliferation, metastasis, invasion and chemoresistance. Thus is an oncogene that functions by inducing stem cells' circuitries and heterogeneity in cancers. Understanding NANOG's role in various cancers may lead to it becoming a therapeutic target to halt cancer progression. The NANOG network can also be targeted to resensitize resistant cancer cells to conventional therapies. The current review focuses on NANOG regulation in the various signaling networks leading to cancer progression and chemoresistance, and highlights the therapeutic aspect of targeting NANOG in various cancers.
转录因子NANOG调节胚胎细胞的自我更新和多能性，其下调会导致细胞分化。最近的研究表明，NANOG在各种癌症中的上调以及不同分子的表达调控，与诱导增殖、转移、侵袭和化疗耐药性有关。因此，NANOG是一种癌基因，通过诱导癌症中干细胞的信号通路和异质性发挥作用。了解NANOG在各种癌症中的作用可能会使其成为阻止癌症进展的治疗靶点。NANOG网络也可以作为靶点，使耐药癌细胞对传统疗法重新敏感。本综述重点关注NANOG在导致癌症进展和化疗耐药性的各种信号网络中的调控，并强调了在各种癌症中靶向NANOG的治疗意义。
