Department of Zoology, Avinashilingam Institute for Home Science and Higher Education for Women, Coimbatore 641043, India.
Department of Genetics and Molecular Biology, Sankara Nethralaya, Chennai 600006, India.
Eur J Pharmacol. 2019 Jun 5;852:51-57. doi: 10.1016/j.ejphar.2019.03.003. Epub 2019 Mar 2.
Cancer incidence, metastasis, drug resistance and recurrence are still the critical issues of oncological diseases especially Ovarian cancer (OC). It has been suggested that drug resistance and disease relapse are the main causes for the aggressive nature of OC. There is an immediate need to develop novel strategies to understand the mechanism to overcome chemoresistance. Nanog has been found to regulate stemness like cells inside the cancer cells that are termed as Cancer Stem Cells (CSCs). These cells show high self-renewal capacity with a peculiar potential in tumour initiation, heterogeneity, progression, metastasis, recurrence, radiotherapy and multi drug resistance. Recent studies have demonstrated that Nanog, a key transcription factor for pluripotency, has been playing a major role in chemoresistance. In this review, we address the functions of Nanog in both normal and cancer cells, how Nanog is involved in OC tumorigenesis and chemoresistance. This review also highlights the methods that are used for targeting Nanog as a remedy for treating OC. Thus, through this review, we predict that these concepts will open new avenues of research in ovarian cancer stem cells, and would propose Nanog as a target to improve the outcome of chemotherapy.
癌症的发病率、转移、耐药和复发仍然是肿瘤疾病的关键问题，特别是卵巢癌（OC）。已经有人提出，耐药和疾病复发是 OC 侵袭性的主要原因。因此，我们迫切需要开发新的策略来了解克服化疗耐药的机制。Nanog 已被发现可以调节肿瘤细胞内的类似干细胞的细胞，这些细胞被称为癌症干细胞（CSC）。这些细胞具有高自我更新能力，在肿瘤起始、异质性、进展、转移、复发、放疗和多药耐药方面具有独特的潜力。最近的研究表明，Nanog 作为多能性的关键转录因子，在化疗耐药中起着重要作用。在这篇综述中，我们讨论了 Nanog 在正常细胞和癌细胞中的功能，以及 Nanog 如何参与 OC 的肿瘤发生和化疗耐药。这篇综述还强调了靶向 Nanog 的方法，将其作为治疗 OC 的一种方法。因此，通过这篇综述，我们预测这些概念将为卵巢癌干细胞的研究开辟新的途径，并提出 Nanog 作为提高化疗效果的靶点。
