Gynaecological Oncology Radiotherapy (Inpatient Area 1), The Affiliated Cancer Hospital of Xinjiang Medical University, Urumqi, China.
School of Public Health, Xinjiang Medical University, Urumqi, China.
J Obstet Gynaecol. 2022 Jul;42(5):1347-1351. doi: 10.1080/01443615.2021.1963691. Epub 2021 Oct 25.
Cervical cancer patients in early-stage cervical cancer (ECC) were divided into pelvic lymph node (PLN) metastasis and non-PLN metastasis group. Single nucleotide polymorphism (SNP) genotyping for the gene was conducted and plasma VEGF levels were measured. Multivariate analysis was performed to assess the correlation between SNPs of the gene and PLN metastasis. We found that SNP of the rs2010963 was independently associated with PLN metastasis. GG and CG genotype had increased susceptibility to PLN metastasis compared with CC genotype, and moreover, OR was higher in GG genotype than in CG genotype. Plasma VEGF levels were lowest in CC genotype, intermediate in GC genotype and highest in GG genotype. In summary, the SNP of the rs2010963 affected susceptibility to PLN metastasis in patients with ECC, and GG and CG genotype had increased susceptibility compared with CC genotype. The potential mechanism was associated with elevated plasma VEGF levels.Impact Statement The positive expression of vascular endothelial growth factor (VEGF) is correlated with higher risk of lymph node metastasis among cervical cancer patients, and VEGF levels of patients with pelvic lymph node (PLN) metastasis are significantly higher than those without PLN metastasis. Additionally, single nucleotide polymorphisms (SNPs) of the gene have been indicated to be correlated with individual susceptibility to tumours and expression and protein production of VEGF. The SNP of the rs2010963 was independently associated with PLN metastasis in patients with early-stage cervical cancer (ECC). The GG and CG genotype of the rs2010963 had increased susceptibility to PLN metastasis compared with CC genotype. Plasma VEGF levels were lowest in the CC genotype, intermediate in the GC genotype and highest in the GG genotype. The SNP of the rs2010963 affected susceptibility to PLN metastasis in patients with ECC, and the potential mechanism was associated with elevated plasma VEGF levels.
早期宫颈癌（ECC）患者分为盆腔淋巴结（PLN）转移和非 PLN 转移组。对基因进行单核苷酸多态性（SNP）基因分型，并测量血浆 VEGF 水平。进行多变量分析以评估基因的 SNP 与 PLN 转移之间的相关性。我们发现基因的 SNP rs2010963 与 PLN 转移独立相关。与 CC 基因型相比，GG 和 CG 基因型对 PLN 转移的易感性增加，并且 GG 基因型的 OR 高于 CG 基因型。CC 基因型的血浆 VEGF 水平最低，GC 基因型居中，GG 基因型最高。总之，rs2010963 的 SNP 影响 ECC 患者 PLN 转移的易感性，与 CC 基因型相比，GG 和 CG 基因型的易感性增加。潜在机制与血浆 VEGF 水平升高有关。
血管内皮生长因子（VEGF）的阳性表达与宫颈癌患者发生淋巴结转移的风险较高相关，且发生盆腔淋巴结（PLN）转移的患者 VEGF 水平明显高于未发生 PLN 转移的患者。此外，血管内皮生长因子（VEGF）基因的单核苷酸多态性（SNP）与个体对肿瘤的易感性以及 VEGF 的表达和蛋白产生有关。rs2010963 的 SNP 与早期宫颈癌（ECC）患者的 PLN 转移独立相关。rs2010963 的 GG 和 CG 基因型与 CC 基因型相比，对 PLN 转移的易感性增加。rs2010963 的 CC 基因型的血浆 VEGF 水平最低，GC 基因型居中，GG 基因型最高。rs2010963 的 SNP 影响 ECC 患者 PLN 转移的易感性，潜在机制与血浆 VEGF 水平升高有关。
