儿童 COVID-19. 二：发病机制、疾病谱和管理。
COVID-19 in children. II: Pathogenesis, disease spectrum and management.
机构信息
Discipline of Child and Adolescent Health, University of Sydney, The Children's Hospital at Westmead, Sydney, New South Wales, Australia.
NSW Health Pathology-Nepean, Nepean Hospital, Sydney, New South Wales, Australia.
出版信息
J Paediatr Child Health. 2022 Jan;58(1):46-53. doi: 10.1111/jpc.15811. Epub 2021 Oct 25.
Abstract
The global disruption of the COVID-19 pandemic has impacted the life of every child either directly or indirectly. This review explores the pathophysiology, immune response, clinical presentation and treatment of COVID-19 in children, summarising the most up-to-date data including recent developments regarding variants of concern. The acute infection with SARS-CoV-2 is generally mild in children, whilst the post-infectious manifestations, including paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS) and 'long COVID' in children, are more complex. Given that most research on COVID-19 has focused on adult cohorts and that clinical manifestations, treatment availability and impacts differ markedly in children, research that specifically examines COVID-19 in children needs to be prioritised.
摘要
COVID-19 大流行的全球蔓延，直接或间接地影响了每一个儿童的生活。本综述探讨了 COVID-19 在儿童中的病理生理学、免疫反应、临床表现和治疗，总结了包括最近关于关注变体的最新数据。SARS-CoV-2 的急性感染在儿童中通常较轻，而感染后表现，包括与 SARS-CoV-2 相关的儿童炎症性多系统综合征（PIMS-TS）和“长 COVID”，则更为复杂。鉴于大多数 COVID-19 研究都集中在成年人群体，而且儿童的临床表现、治疗方法和影响明显不同，因此需要优先研究专门针对儿童 COVID-19 的研究。
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