Department of Gastroenterological Surgery, Osaka University Graduate School of Medicine, 2-2-E2 Yamada-oka, Suita City, Osaka, 565-0871, Japan.
Department of Surgery, Osaka General Medical Center, Osaka, Japan.
Surg Today. 2022 Apr;52(4):624-632. doi: 10.1007/s00595-021-02389-0. Epub 2021 Oct 25.
To evaluate if nutritional supplements can attenuate postoperative catabolism in esophageal cancer patients after radical esophagectomy.
We analyzed data prospectively from 30 patients who underwent curative esophagectomy for esophageal cancer between August and December, 2019. We compared postoperative nitrogen balance and changes in body composition between patients who received protein-enhanced enteral feeds (PEF) or other enteral feeds (OF).
Postoperative enteral feeding was administered safely to all patients. The average nitrogen balance was significantly higher in the PEF group than in the OF group on postoperative days (PODs) 3 (2.41 vs. - 1.50 g, P = 0.002), 4 (3.74 vs. - 0.08 g, P = 0.006), and 5 (3.27 vs. 0.11 g, P = 0.031). The cumulative nitrogen balance in the 7 days after surgery was significantly higher in the PEF group than in the OF group (6.12 vs. - 8.40 g, P = 0.025). The bodyweight loss and lean body mass loss on POD 14 were equivalent in the two groups (bodyweight loss 3.70 vs. 2.87%, P = 0.25; lean body mass loss, 4.34 vs. 1.91%, P = 0.33).
PEF improved the postoperative nitrogen balance significantly in patients who underwent esophagectomy.
评估营养补充剂是否可以减轻根治性食管癌手术后患者的术后分解代谢。
我们对 2019 年 8 月至 12 月期间接受根治性食管癌切除术的 30 例患者的前瞻性数据进行了分析。我们比较了接受高蛋白肠内喂养（PEF）或其他肠内喂养（OF）的患者术后氮平衡和身体成分变化。
所有患者均安全接受术后肠内喂养。PEF 组患者术后第 3 天（2.41 对-1.50g，P=0.002）、第 4 天（3.74 对-0.08g，P=0.006）和第 5 天（3.27 对 0.11g，P=0.031）的平均氮平衡明显高于 OF 组。手术后 7 天的累积氮平衡在 PEF 组明显高于 OF 组（6.12 对-8.40g，P=0.025）。两组患者术后第 14 天的体重减轻和瘦体重减轻相当（体重减轻 3.70%对 2.87%，P=0.25；瘦体重减轻 4.34%对 1.91%，P=0.33）。
PEF 可显著改善食管癌术后患者的术后氮平衡。
