Li Fei, Zhang Yuhan, Shi Peng, Cao Linfeng, Su Liyun, Zhang Yulan, Peng Ke, Lu Roujian, Tan Wenjie, Shen Jun
Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China.
Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China.
Infect Dis Ther. 2022 Feb;11(1):165-174. doi: 10.1007/s40121-021-00548-x. Epub 2021 Oct 25.
Since the global outbreak of COVID-19, there has been a significant reduction in pediatric outpatient and emergency visits for infectious diseases. The purpose of this study was to analyze the changes in respiratory viruses in children with community-acquired pneumonia (CAP) in Shanghai in the past 10 years, especially in the first year after COVID-19.
We conducted a retrospective, observational study; the results for eight common respiratory viruses (respiratory syncytial virus (RSV), influenza virus A and B, parainfluenza virus 1-3 (PIV), adenovirus (ADV) and human metapneumovirus) tested by direct fluorescent antibody assays in hospitalized CAP cases in Children's Hospital of Fudan University during 2010-2020 were analyzed.
Of the 5544 hospitalized CAP patients included in this study, 20.2% (1125/5544) were positive for the eight respiratory viruses. The top three pathogens were RSV, PIV3 and ADV, detected from 9.8% (543/5544), 5.3% (294/5544) and 2.0% (111/5544) of the samples, respectively. RSV had the highest positive rates among children < 2 years old. In 2020, the detection rate of all viruses showed a sharp decline from February to August compared with the previous 9 years. When the Shanghai community reopened in August 2020, the detection rate of eight viruses rebounded significantly in September.
These eight respiratory viruses, especially RSV and PIV, were important pathogens of CAP in Shanghai children in the past 10 years. The COVID-19 pandemic had a significant impact on the detection rates for eight respiratory viruses in children with CAP in Shanghai.
自新冠疫情全球爆发以来，儿科传染病门诊和急诊就诊人数显著减少。本研究旨在分析过去10年上海社区获得性肺炎（CAP）患儿儿童儿童儿童呼吸道病毒的变化，尤其是新冠疫情后的第一年。
我们进行了一项回顾性观察研究；分析了2010 - 2020年复旦大学附属儿科医院住院CAP病例中通过直接荧光抗体检测法检测的8种常见呼吸道病毒（呼吸道合胞病毒（RSV）、甲型和乙型流感病毒、副流感病毒1 - 3型（PIV）、腺病毒（ADV）和人偏肺病毒）的检测结果。
本研究纳入的5544例住院CAP患者中，20.2%（1125/5544）的患者8种呼吸道病毒检测呈阳性。前三位病原体为RSV、PIV3和ADV，分别从9.8%（543/5544）、5.3%（294/5544）和2.0%（111/5544）的样本中检测到。RSV在2岁以下儿童中的阳性率最高。2020年，与前9年相比，2月至8月所有病毒的检测率均大幅下降。2020年8月上海社区重新开放时，8种病毒的检测率在9月显著反弹。
这8种呼吸道病毒，尤其是RSV和PIV，是过去10年上海儿童CAP的重要病原体。新冠疫情对上海CAP儿童8种呼吸道病毒的检测率有显著影响。
