Department of Biology, College of Science, King Khalid University, Abha, Saudi Arabia.
Department of Anatomy and Histology, Faculty of Medicine, Sana'a University, Sana'a, Yemen.
IET Nanobiotechnol. 2021 Feb;15(1):58-67. doi: 10.1049/nbt2.12000. Epub 2020 Dec 15.
Titanium dioxide nanoparticles (TiO NPs) have novel application and are used in many household application, nanomedicine, agriculture, industries and pharmaceutical products. These applications may be accompanied with potential risk in human health and the ecosystems. The current study was carried out to find out the acute damage that might be induced by TiO NPs in the heart and testis. Three groups of Wistar albino rats (Rattus norvegicus) were subjected to a single dose TiO NPs (126, 252, 378 mg/kg bw). Cardiac and testicular biopsies from each animal under study were handled for histological and histochemical examination. Rats exposed to TiO NPs demonstrated the following cardiac alterations: myofibres wavy appearance, myofibre disarray, partial cross striation, cardiomyocytes hydropic degeneration together with vacuolation and nuclear alterations. Moreover, acute exposure to TiO NPs induced the following testicular alterations: spermatocytes degeneration, spermatids sloughing and interstitial edema. The presented cardiac and testicular alterations were dose dependent. From the findings of the present study, it might be concluded that TiO nanomaterials are capable of inducing acute cardiac and testicular damage that is dose dependent and could adversely affect the function of the vital organs.
二氧化钛纳米粒子（TiO NPs）具有新颖的应用，用于许多家庭应用、纳米医学、农业、工业和制药产品。这些应用可能伴随着人类健康和生态系统的潜在风险。本研究旨在发现 TiO NPs 可能对心脏和睾丸造成的急性损伤，并进行测试。三组 Wistar 白化大鼠（Rattus norvegicus）接受了单次剂量的 TiO NPs（126、252、378 mg/kg bw）。对每只研究动物的心脏和睾丸活检进行了组织学和组织化学检查。暴露于 TiO NPs 的大鼠表现出以下心脏改变：肌纤维波浪状外观、肌纤维排列紊乱、部分横纹消失、心肌细胞水样变性伴空泡形成和核改变。此外，急性暴露于 TiO NPs 还诱导了以下睾丸改变：精母细胞变性、精子细胞脱落和间质水肿。呈现的心脏和睾丸改变呈剂量依赖性。根据本研究的结果，可以得出结论，TiO 纳米材料能够诱导急性心脏和睾丸损伤，这种损伤呈剂量依赖性，并可能对重要器官的功能产生不利影响。
