Key Laboratory of Environmental Medicine and Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing 210009, China.
Nanoscale Res Lett. 2013 Jan 25;8(1):51. doi: 10.1186/1556-276X-8-51.
The paper is aimed to investigate the toxicity of nano-TiO2 and its potential harmful impact on human health using meta-analysis of in vitro and short-time animal studies. Data were retrieved according to included and excluded criteria from 1994 to 2011. The combined toxic effects of nano-TiO2 were calculated by the different endpoints by cell and animal models. From analysis of the experimental studies, more than 50% showed positive statistical significance except the apoptosis group, and the cytotoxicity was in a dose-dependent but was not clear in size-dependent manner. Nano-TiO2 was detained in several important organs including the liver, spleen, kidney, and brain after entering the blood through different exposure routes, but the coefficient of the target organs was altered slightly from animal models. It is possible that nano-TiO2 can induce cell damage related to exposure size and dose. Further studies will be needed to demonstrate that nanoparticles have toxic effects on human body, especially in epidemiological studies.
本研究采用体外和短期动物实验的荟萃分析，旨在探讨纳米 TiO2 的毒性及其对人类健康的潜在有害影响。本研究根据纳入和排除标准，从 1994 年至 2011 年检索数据。通过细胞和动物模型，根据不同的终点计算纳米 TiO2 的综合毒性效应。从实验研究分析，除了凋亡组，超过 50%的结果显示出阳性统计学意义，细胞毒性呈剂量依赖性，但与尺寸依赖性不明确。纳米 TiO2 通过不同的暴露途径进入血液后，会在几个重要器官（包括肝脏、脾脏、肾脏和大脑）中被滞留，但从动物模型来看，靶器官的系数变化很小。纳米 TiO2 可能会引起与暴露大小和剂量相关的细胞损伤。需要进一步的研究来证明纳米颗粒对人体具有毒性作用，特别是在流行病学研究中。
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