Department of Surgical Research and Techniques, Semmelweis University, Budapest, Hungary.
Department of Pathology and Experimental Cancer Research, Semmelweis University, Budapest, Hungary.
IET Nanobiotechnol. 2021 Aug;15(6):565-574. doi: 10.1049/nbt2.12015. Epub 2021 Feb 2.
Hernia is a defect of the abdominal wall. Treatment is principally surgical mesh implantation. Non-degradable surgical meshes produce numerous complications and side-effects such as inflammatory response, mesh migration and chronic pain. In contrast, the biodegradable, poly (vinyl alcohol) (PVA) based polymers have excellent chemical, mechanical and biological properties and after their degradation no chronic pain can be expected. The toxicology of PVA solution and fibers was investigated with Human dermal fibroblast- Adult cell line. Implantation tests were observed on long-term contact (rat) and large animal (swine) models. To measure the adhesion formation, Diamond and Vandendael score were used. Macroscopical and histological responses were graded from the samples. In vitro examination showed that PVA solution and fibers are biocompatible for the cells. According to the implantation tests, all samples were integrated into the surrounding tissue, and there was no foreign body reaction. The average number of adhesions was found on the non-absorbable suture line. The biocompatibility of the PVA nanofiber mesh was demonstrated. It has a non-adhesive, non-toxic and good quality structure which has the potential to be an alternative solution for the part of the hernia mesh.
疝是腹壁的缺陷。治疗主要是手术网片植入。不可降解的手术网片会产生许多并发症和副作用，如炎症反应、网片迁移和慢性疼痛。相比之下，可生物降解的聚乙烯醇（PVA）基聚合物具有优异的化学、机械和生物学性能，在其降解后不会产生慢性疼痛。用成人皮肤成纤维细胞系对 PVA 溶液和纤维的毒理学进行了研究。在长期接触（大鼠）和大动物（猪）模型上进行了植入试验观察。为了测量粘连形成，使用了 Diamond 和 Vandendael 评分。从样本中对宏观和组织学反应进行了分级。体外检查表明，PVA 溶液和纤维对细胞具有生物相容性。根据植入试验，所有样本都与周围组织整合在一起，没有异物反应。在不可吸收缝线处发现的粘连数量平均。证明了 PVA 纳米纤维网的生物相容性。它具有非粘连、无毒和良好质量的结构，有可能成为疝网片的一部分的替代解决方案。
