Department of Surgery, Section of Minimally Invasive Surgery, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8109, St. Louis, MO 63110, USA.
Hernia. 2012 Feb;16(1):69-76. doi: 10.1007/s10029-011-0854-5. Epub 2011 Jul 12.
The objective of this study was to determine the mesh contracture, adhesion, tissue ingrowth, and histologic characteristics of a novel absorbable barrier mesh (Ventrio™ ST Hernia Patch) compared to existing permanent (Ventrio™ Hernia Patch) and absorbable barrier meshes (Sepramesh™ IP Composite and PROCEED™ Surgical Mesh).
Standard laparoscopic technique was utilized to bilaterally implant meshes in 20 female Yorkshire pigs (n = 5 pigs/group). Meshes were fixated to the intact peritoneum with SorbaFix™ absorbable fixation devices. Mesh contracture, adhesion coverage, and adhesion tenacity were evaluated after 4 weeks. T-Peel testing and hematoxylin and eosin (H&E) staining were utilized to assess tissue ingrowth and host response.
A significantly greater percent area contracture was demonstrated for PROCEED™ (26.9%) compared to Ventrio™ ST (8.8%), Ventrio™ (14.5%) and Sepramesh™ (9.2%). Ventrio™ ST demonstrated similar adhesion area, tenacity, and tissue ingrowth compared to all other meshes. Histological scoring revealed a comparable host inflammatory response for all meshes, with a few exceptions. A greater number of giant cells were observed in Ventrio™ ST and Sepramesh™ near the multifilament polyglycolic acid (PGA) fibers; a greater number of macrophages were observed in PROCEED™ compared to Ventrio™; and a greater number of neutrophils were observed in PROCEED™, compared to Sepramesh™ (P < 0.05). Focal areas of hemorrhage were also observed on the visceral surface of PROCEED™.
Ventrio™ ST Hernia Patch demonstrated comparable contracture, adhesion, tissue ingrowth, and histologic characteristics compared to existing permanent and absorbable barrier meshes. Host inflammatory and fibrotic responses for all four meshes were minimal and representative of a biocompatible response.
本研究旨在比较新型可吸收屏障网片（Ventrio ST 疝修补片）与现有永久性（Ventrio 疝修补片）和可吸收屏障网片（Sepramesh IP 复合网片和 PROCEED 外科网片）的网片挛缩、粘连、组织长入和组织学特性。
采用标准腹腔镜技术将网片双侧植入 20 只雌性约克夏猪（每组 5 只猪）。使用 SorbaFix 可吸收固定装置将网片固定在完整的腹膜上。4 周后评估网片挛缩、粘连覆盖和粘连强度。采用 T 剥离试验和苏木精-伊红（H&E）染色评估组织长入和宿主反应。
与 Ventrio ST（8.8%）、Ventrio（14.5%）和 Sepramesh（9.2%）相比，PROCEED（26.9%）显示出更大的面积收缩百分比。Ventrio ST 与所有其他网片相比，其粘连面积、强度和组织长入相似。组织学评分显示所有网片的宿主炎症反应相似，仅存在一些例外。在 Ventrio ST 和 Sepramesh 中靠近多股聚乙二醇酸（PGA）纤维的部位观察到更多的巨细胞；与 Ventrio 相比，在 PROCEED 中观察到更多的巨噬细胞；与 Sepramesh 相比，在 PROCEED 中观察到更多的中性粒细胞（P < 0.05）。还在 PROCEED 的内脏表面观察到局灶性出血区。
与现有的永久性和可吸收屏障网片相比，Ventrio ST 疝修补片表现出相似的挛缩、粘连、组织长入和组织学特性。所有四种网片的宿主炎症和纤维化反应均较小，代表了一种生物相容性反应。
