Morris T C, Vincent P C, Gunz F W, Sutherland R, Zbroja R, Irvine A E, Forrest P R
Leuk Res. 1987;11(2):109-17. doi: 10.1016/0145-2126(87)90016-6.
Five patients with Ph1 +ve chronic granulocytic leukaemia and massive splenomegaly were given induction therapy with splenic irradiation, and their peripheral blood leucocyte count and granulocyte macrophage progenitor (CFU-GM) concentration monitored during the following six hours. In each patient there was a greater fall in CFU-GM than would have been expected from the fall in leucocyte count, but no evidence of a plasma inhibitor was found to explain the disproportionate reduction in CFU-GM. The difference between the estimated and observed decrease in CFU-GM/1 following splenic irradiation indicates a highly dynamic traffic of CFU-GM from the spleen to other organs in chronic granulocytic leukaemia.
对5例伴有巨大脾肿大的Ph1阳性慢性粒细胞白血病患者进行脾区照射诱导治疗，并在随后6小时内监测其外周血白细胞计数和粒细胞巨噬细胞祖细胞（CFU-GM）浓度。每位患者的CFU-GM下降幅度均大于根据白细胞计数下降所预期的幅度，但未发现血浆抑制剂可解释CFU-GM不成比例减少的现象。脾区照射后CFU-GM/1估计下降值与观察下降值之间的差异表明，在慢性粒细胞白血病中，CFU-GM从脾脏到其他器官的转运具有高度动态性。
